About the Center

The Mahidol Vivax Research Unit MVRU), established in March 2011, is a Center of Excellence focused on the biology of malaria parasite transmission, including mosquito and human liver stages, in Non-African countries. MVRU is based at the Faculty of Tropical Medicine, Mahidol University (FTM-MU), Bangkok, Thailand.

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Research

Thailand is a malaria-endemic country, where all human malaria species, P. falciparum, P. vivax, P. malariae, and P. ovale, have been found. Cross-border migration is a major cause of malaria transmission in the region. Drug-resistant parasites, both P. falciparum and P. vivax, have been reported in the country.

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Collaborations

In collaboration with, and funding from, various international institutes, such as NIH, US DoD, US NIAID, and the Bill & Melinda Gates Foundation, the MVRU continues to study malaria transmission and biology of transmission stages (gametocytes and sporogonic stages) working to support vaccine and new drug development.

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Publications

2012

Longitudinal in vitro surveillance of Plasmodium falciparum sensitivity to common anti-malarials in Thailand between 1994 and 2010. Parker D, Lerdprom R, Srisatjarak W, Yan G, Sattabongkot J, Wood J, Sirichaisinthop J, Cui L. Malar J. 11(1): 290. 2012.

Use of a Rhesus Plasmodium cynomolgi Model to Screen for Anti-Hypnozoite Activity of Pharmaceutical Substances. Deye GA, Gettayacamin M, Hansukjariya P, Im-Erbsin R, Sattabongkot J, Rothstein Y, Macareo L, Fracisco S, Bennett K, Magill AJ, Ohrt C. Am J Trop Med Hyg. 86(6):931-5. 2012.

2011

Stable allele frequency distribution of the polymorphic region of SURFIN(4.2) in Plasmodium falciparum isolates from Thailand. Kaewthamasorn M, Yahata K, Alexandre JS, Xangsayarath P, Nakazawa S, Torii M, Sattabongkot J, Udomsangpetch R, Kaneko O. Parasitol Int. 2011 Dec 27.

Evaluation of loop-mediated isothermal amplification (LAMP) for malaria diagnosis in a field setting. Sirichaisinthop J, Buates S, Watanabe R, Han ET, Suktawonjaroenpon W, Krasaesub S, Takeo S, Tsuboi T, Sattabongkot J. Am J Trop Med Hyg. 2011 Oct;85(4):594-6.

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Lab Accomplishments

  • Developed in vitro culture system for blood-stage and liver-stage P. vivax and P. falciparum, and in vitro culture of P. vivax ookinetes
  • Established P. falciparum gametocyte production line from field isolates in Thailand
  • Developed a protocol for a membrane feeding assay for P. vivax TBV
  • Developed protocols for the enrichment of blood-stage parasites from patient blood and preparation of ookinetes, oocysts, and sporozoites, from mosquitoes for transcriptome and proteome analysis
  • Developed protocols for parasite antigen preparation from patient blood and infected mosquitoes for immunological study
  • Developed a protocol for malaria diagnosis by LAMP
  • Developed a protocol for the measurement of malaria infection in mosquitoes by ELISA for CSP (circumsporozoite protein) antigens
  • Developed a protocol to identify CSP210 and 247 type antigens in patient blood samples


Training

The Center offers training in malaria research for undergraduate, graduate students and researchers from Mahidol University, other Universities in Thailand, as well as other countries. We aim to increase research capacity among future researchers, and to enhance international collaboration among institutes with different disciplines.

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Media Release

20 April 2012

The Mahidol Vivax Research Unit Joins the Asia Pacific Malaria Elimination Network

The Asia Pacific Malaria Elimination Network (APMEN) today announces that The Mahidol Vivax Research Unit is one of two new Partner Institutions to join the Network. The Mahidol Vivax Research Unit (MVRU) established in March 2011 is unique as it is dedicated to the study of Plasmodium vivax and non falciparum malaria. Its establishment at Mahidol University in Thailand is important to the region as Mahidol has a long and impressive record in the field of tropical disease medicine and research.

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