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| Research Projects |
| The ongoing research works include: |
1. |
Protective antibodies against erythrocyte invasion ligands in Plasmodium falciparum in Thailand. |
2. |
Development of human monoclonal antibody specific to dengue virus. |
3. |
Immunogenicity and safety of inactivated vero cell derived Japanese Encephalitis vaccine in Thai children. |
4. |
Safety and immunogenicity of Heptavalent Pneumococcal Conjugate vaccine in prevention of pneumococcal diseases in high risk children. |
5. |
A phase III, partially-blinded, multi-centre, controlled study to assess the safety and immunogenicity of GlaxoSmithKline (GSK) Biologicals’ meningococcal serogroup ACWY tetanus-toxoid conjugate vaccine (MenACWY-TT) versus one dose of GSK Biologicals’ meningococcal polysaccharides A, C, W-135 and Y vaccine, Mencevax™ ACWY and to assess the clinical comparability of two lots of MenACWY-TT administered in healthy subjects aged 18 through 25 years. |
6. |
Efficacy and safety of dengue vaccine in healthy children age 4 to 11 years in Thailand (CYD23). |
7. |
A controlled study of the safety and immunogenicity of ChimerVaxTM Japanese encephalitis vaccine in Thai toddlers and children (JEC01 extension). |
8. |
Evaluation of long term immunity against rabies in children vaccinated with different pre-exposure regimens of PCEC (Rabipur®) and the immunity after two IM injections of PCEC (Rabipur®) post-exposure in the children previously vaccinated with PCEC pre-exposure regimens (I49P6 extension). |
9. |
Evaluation of long-term-immunity against JE in children vaccinated with JE vaccine (Extension of study M49P2 and I49P6) amendment 1 (I49P6) amendment1 (I49P6 JE add amendment 1). |
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| The important and complete research works include: |
1. |
Epidemiological study of dengue infection in children in Ratchaburi Province (RAT0148). |
2. |
Safety and immunogenicity of tetravalent dengue vaccine formulations in healthy Thai children, clinical trial protocol amendment 3 version number 2.0 date 09 August 2004 (DEN06199 amendment 3). |
3. |
Dengue antibodies level and incidence of dengue infection in pre-school-aged children (Data analysis) (DEN0448). |
4. |
Socio-behavioral focus group study of community knowledge and attitudes related to the dengue fever and an up-coming dengue vaccination in Ratchaburi, Thailand. |
5. |
Study of dengue antibody in infants. |
6. |
Evaluation of long-term-immunity against rabies in children vaccinated with Purified Chick Embryo Cell Rabies Vaccine (Rabipur) in different pre-exposure regimens and boosted after one year. |
7. |
Favirab tm post prescription event monitoring. |
8. |
Immunogenicity and safety of PVRV postexposure vaccination in Thai children. |
9. |
Albendazole efficacy in reducing intestinal parasites, improving nutritional, physical status and intelligence in Thai school children infected with common geohelminths. |
10. |
A randomized comparative trial with suppositories artesunate plus mefloquine and oral artesunate plus mefloquine in uncomplicated symptomatic falciparum malaria in children in Thailand. |
11. |
Long term rabies antibody profiles in children after id and im administration of purified Vero cell rabies vaccine pre-exposure vaccination and effect of booster doses. |
12. |
Safety, tolerability and immunogenicity of the iphth acellular iphtheri vaccine combined with iphtheria and tetanus toxoid (DtaP). |
13. |
Efficacy, safety and tolerability of Tiorfan in the treatment of acute diarrhea in children. |
14. |
The study of immunogenicity and adverse reaction of JE vaccine (liquid form) Beijing strain produced by the Government Pharmaceutical Organization of Thailand in Thai children. |
15. |
Early immune response to multi-sites intramuscular injection of purified Vero cell rabies vaccine (PVRV) for rabies post-exposure treatment. |
16. |
Clinical trial and pharmacokinetic of artesunate suppositories in Thai children with acute uncomplicated falciparum malaria. |
17. |
A phase II, pilot, randomized, open-label, single-center study to evaluate immunogenicity, safety and booster response of 3 full intramuscular doses versus 3 half intramuscular dose versus 3 intradermal doses versus 2 intradermal doses of PCEC rabies vaccine (Rabipur) administered concomitantly with Japanese encephalitis vaccine as a pre-exposure regimen in 12 to 18 months old toddlers in Thailand. |
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| Research-Linkage |
1. |
Pediatric Dengue Vaccine Initiative (PDVI). |
2. |
Department of Disease Control, MOPH, Thailand |
3. |
Sanofi Pasteur |
4. |
Novartis Vaccine |
5. |
Department of Virology, AFRIMS, Bangkok , Thailand |
