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Contents |
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Contents |
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Foreword |
xi |
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Introduction |
xv |
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Punnee Pitisuttithum, Donald P. Francis, José Esparza Prasert Thongcharoen |
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Chapter 1 : Setting the stage |
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The Challenge of Developing an HIV Vaccine |
3 |
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José Esparza, Nina Russell and Helene Gayle |
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Chapter 2 : The AIDS Epidemic in Thailand |
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Molecular Epidemiology of HIV in Thailand |
31 |
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Chantapong Wasi, Ruengpung Sutthent and Saladin Osmanov |
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The Thai Response to the HIV/AIDS Epidemic |
53 |
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Wiput Phoolcharoen |
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Chapter 3 : HIV Vaccine Research in Thailand:National Perspective |
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Overview of HIV Vaccine Research in Thailand |
83 |
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Punnee Pitisuttithum |
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The Thai National Plan on HIV Vaccine Research and Development |
95 |
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Supachai Rerks-Ngam, Chirasak Khamboonruang, Prayura Kunasol and Prasert Thongcharoen |
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National Ethical Review Board Framework |
103 |
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Vichai Chokevivat |
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Chapter 4 : Phase I/II HIV Vaccine Trials in Thailand |
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The First HIV Vaccine Trial in Thailand |
119 |
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Praphan Phanuphak |
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The Vaccine Trial Center, Faculty of Tropical Medicine, Mahidol University |
131 |
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Punnee Pitisuttithum, Sricharoen Migasena and Pratap Singhasivanon |
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The Armed Forces Research Institute of Medical Sciences (AFRIMS): Role in HIV Vaccine Development |
153 |
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Partricia A. Morgan, Mark S. de Souza, Thippawan Chuenchitra, Chirapa Eamsila, Bruce R. Merrell, Cheodchai Chuenchitra and Sorachai Nitayaphan |
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The Research Institute for Health Sciences (RIHES), Chiang Mai University, Thailand |
167 |
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Vinai Suriyanon |
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Chapter 5 : International Collaborative Efforts |
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Thai and US Military HIV Research Program |
181 |
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Arthur E. Brown, Deborah Birx and Jerome H. Kim |
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The HIV Netherlands-Australia-Thailand Research Collaboration (HIV-NAT) |
195 |
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Praphan Phanuphak |
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Collaboration between Thailand and Japan on Research and Development of an HIV Vaccine |
209 |
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Paijit Warachit, Pathom Sawanpanyalert, Duanthanorm Promkhatkaew, Jotika Boon-Long and Mitsuo Honda |
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Chapter 6 : Developing Cohorts for Phase III Trials of Candidate HIV Vaccines |
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Chiang Mai Community Cohort |
221 |
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Chirasak Khamboonruang |
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The Bangkok Metropolitan Administration (BMA) Cohort of Injecting Drug Users (IDUs) |
241 |
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Suphak Vanichseni, Dwip Kitayaporn and Timothy D. Mastro |
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Community Cohorts in Rayong and Chon Buri |
251 |
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Michael W. Benenson |
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Chapter 7 : Conducting Phase III Trials of Candidate HIV Vaccines |
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Challenges in Performing Phase III Trials of HIV Candidate Vaccines |
265 |
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Donald P. Francis |
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Phase III Efficacy Trial of Bivalent B/E rgp120 HIV Vaccine (AIDSVAX˙B/E) in Bangkok |
275 |
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Punnee Pitisuttithum, Suphak Vanichseni, Dwip Kitayaporn and Kachit Choopanya |
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The Rayong-Chonburi Community Phase III HIV Vaccine Trial |
293 |
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Supachai Rerks-Ngam, Punnee Pitisuttithum, Dwip Kitayaporn, Chirasak Khamboonruang, Sorachai Nitayaphan, Arthur E. Brown, Deborah Birx, Jerome H. Kim and Prayura Kunasol |
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Data Management for HIV Vaccine Efficacy Trials-Infrastructure Strengthening for Clinical Research in Thailand |
307 |
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Dwip Kitayaporn |
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From “Guinea Pigs” to “guinea pigs:” Community Awareness and Response to AIDS Vaccine Research and Development in Thailand |
315 |
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Nusara Thaitawat |
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Chapter 8 : Epilogue |
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Projection on HIV Vaccine Research in Thailand in the Next Decade |
329 |
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Praphan Phanuphak |
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Lessons Learnt |
327 |
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Punnee Pitisuttithum, Donald P. Francis, Jose Esparza, Prasert Thongcharoen |
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Index |
344 |
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Biographies of Editors |
350 |
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