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  Contents
Page
 
 
Contents
 
 
Foreword
xi
 
 
Introduction
xv
 
 
Punnee Pitisuttithum, Donald P. Francis, José Esparza Prasert Thongcharoen
 
 
 
 
Chapter 1 : Setting the stage
 
 
The Challenge of Developing an HIV Vaccine
3
 
 
José Esparza, Nina Russell and Helene Gayle
 
 
 
 
Chapter 2 : The AIDS Epidemic in Thailand
 
 
Molecular Epidemiology of HIV in Thailand
31
 
 
Chantapong Wasi, Ruengpung Sutthent and Saladin Osmanov
 
 
 
 
The Thai Response to the HIV/AIDS Epidemic
53
 
 
Wiput Phoolcharoen
 
 
 
 
Chapter 3 : HIV Vaccine Research in Thailand:National Perspective
 
 
Overview of HIV Vaccine Research in Thailand
83
 
 
Punnee Pitisuttithum
 
 
The Thai National Plan on HIV Vaccine Research and Development
95
 
 
Supachai Rerks-Ngam, Chirasak Khamboonruang, Prayura Kunasol and Prasert Thongcharoen
 
 
National Ethical Review Board Framework
103
 
 
Vichai Chokevivat
 
 
 
 
Chapter 4 : Phase I/II HIV Vaccine Trials in Thailand
 
 
The First HIV Vaccine Trial in Thailand
119
 
 
Praphan Phanuphak
 
  The Vaccine Trial Center, Faculty of Tropical Medicine, Mahidol University
131
 
  Punnee Pitisuttithum, Sricharoen Migasena and Pratap Singhasivanon
 
  The Armed Forces Research Institute of Medical Sciences (AFRIMS): Role in HIV Vaccine Development
153
 
  Partricia A. Morgan, Mark S. de Souza, Thippawan Chuenchitra, Chirapa Eamsila, Bruce R. Merrell, Cheodchai Chuenchitra and Sorachai Nitayaphan
 
  The Research Institute for Health Sciences (RIHES), Chiang Mai University, Thailand
167
 
  Vinai Suriyanon
 
   
 
  Chapter 5 : International Collaborative Efforts
 
  Thai and US Military HIV Research Program
181
 
 
Arthur E. Brown, Deborah Birx and Jerome H. Kim
 
 
The HIV Netherlands-Australia-Thailand Research Collaboration (HIV-NAT)
195
 
 
Praphan Phanuphak
 
 
Collaboration between Thailand and Japan on Research and Development of an HIV Vaccine
209
 
 
Paijit Warachit, Pathom Sawanpanyalert, Duanthanorm Promkhatkaew, Jotika Boon-Long and Mitsuo Honda
 
 
 
 
Chapter 6 : Developing Cohorts for Phase III Trials of Candidate HIV Vaccines
 
 
Chiang Mai Community Cohort
221
 
 
Chirasak Khamboonruang
 
 
The Bangkok Metropolitan Administration (BMA) Cohort of Injecting Drug Users (IDUs)
241
 
 
Suphak Vanichseni, Dwip Kitayaporn and Timothy D. Mastro
 
 
Community Cohorts in Rayong and Chon Buri
251
 
 
Michael W. Benenson
 
 
 
 
Chapter 7 : Conducting Phase III Trials of Candidate HIV Vaccines
 
 
Challenges in Performing Phase III Trials of HIV Candidate Vaccines
265
 
 
Donald P. Francis
 
 
Phase III Efficacy Trial of Bivalent B/E rgp120 HIV Vaccine (AIDSVAX˙B/E) in Bangkok
275
 
 
Punnee Pitisuttithum, Suphak Vanichseni, Dwip Kitayaporn and Kachit Choopanya
 
 
The Rayong-Chonburi Community Phase III HIV Vaccine Trial
293
 
 
Supachai Rerks-Ngam, Punnee Pitisuttithum, Dwip Kitayaporn, Chirasak Khamboonruang, Sorachai Nitayaphan, Arthur E. Brown, Deborah Birx, Jerome H. Kim and Prayura Kunasol
 
 
Data Management for HIV Vaccine Efficacy Trials-Infrastructure Strengthening for Clinical Research in Thailand
307
 
 
Dwip Kitayaporn
 
 
From “Guinea Pigs” to “guinea pigs:” Community Awareness and Response to AIDS Vaccine Research and Development in Thailand
315
 
 
Nusara Thaitawat
 
 
 
 
Chapter 8 : Epilogue
 
 
Projection on HIV Vaccine Research in Thailand in the Next Decade
329
 
 
Praphan Phanuphak
 
       
 
Lessons Learnt
327
 
 
Punnee Pitisuttithum, Donald P. Francis, Jose Esparza, Prasert Thongcharoen
 
 
 
 
Index
344
 
 
 
 
Biographies of Editors
350
 
 
 
Last updated: July 14, 2009
 
 
 
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