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| 2008 |
| GENE AMPLIFICATION OF THE MULTIDRUG RESISTANCE 1 GENE OF PLASMODIUM VIVAX ISOLATES FROM THAILAND, LAOS, AND MYANMAR. |
| Imwong M, Pukrittayakamee S, Pongtavornpinyo W, Nakeesathit S, Nair S, Newton P, Nosten F, Anderson TJ, Dondorp A, Day NP, White NJ. |
| Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Rd., Bangkok 10400, Thailand. noi@tropmedres.ac |
| Plasmodium vivax mdr1 gene amplification, quantified by real-time PCR, was significantly more common on the western Thailand border (6 of 66 samples), where mefloquine pressure has been intense, than elsewhere in southeast Asia (3 of 149; P = 0.02). Five coding mutations in pvmdr1, independent of gene amplification, were also found. |
| Published in: Antimicrob Agents Chemother. 2008 Jul;52(7):2657-9. |
Last updated: January 9, 2009
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