GENE AMPLIFICATION OF THE MULTIDRUG RESISTANCE 1 GENE OF PLASMODIUM VIVAX ISOLATES FROM THAILAND, LAOS, AND MYANMAR.
Imwong M, Pukrittayakamee S, Pongtavornpinyo W, Nakeesathit S, Nair S, Newton P, Nosten F, Anderson TJ, Dondorp A, Day NP, White NJ.
Department of Clinical Tropical Medicine, Faculty of Tropical Medicine,
Mahidol University, 420/6 Rajvithi Rd., Bangkok 10400, Thailand.
noi@tropmedres.ac
Plasmodium vivax mdr1 gene amplification, quantified by real-time PCR,
was significantly more common on the western Thailand border (6 of 66
samples), where mefloquine pressure has been intense, than elsewhere in
southeast Asia (3 of 149; P = 0.02). Five coding mutations in pvmdr1,
independent of gene amplification, were also found.
Published in: Antimicrob Agents Chemother. 2008 Jul;52(7):2657-9.