| 2001 |
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| IgE elevation and anti-plasmodium falciparum IgE antibodies: association of high level
with malaria resistance. |
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| Khusmith, S., Panitchakorn, J., Krudsood, S., Wilairatana, P., and Looareesuwan, S.
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| Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University,
Bangkok, Thailand tmskm@mahidol acth |
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| Abstract: The total IgE and anti-Plasmodium falciparum IgE antibodies were determined by
enzyme linked immunosorbent assay (ELISA) in 480 children and adults living in malaria endemic area along Thai-Myanmar border, Kanchanaburi
Province, western Thailand. Approximately 73.13% of tested individuals had elevated levels of total IgE with a range of 160-998 ng/ml. 20.5% of these IgE
were specific to P falciparum blood stage antigens, with a range of 78-353 microg/ml. However, the levels of total IgE were not significantly correlated
with those of specific IgE (r = 0.083). The elevation of anti-P falciparum IgE antibodies seems to be age dependent. The prolonged or repeated exposure
to malaria parasites is necessary for the induction of specific IgE response as indicated by the finding of a significant correlation between the levels of P
falciparum specific IgE and the number of malaria attacks (r = 0.551, p = 0.01). Interestingly, among the specific IgE responders, 20 individuals naturally
exposed to malaria but without clinical malaria reported had high levels of both total IgE and |
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| Published in:Southeast Asian J.Trop.Med.Public Health 32[4], 696-701. 2001. |
