| 2001 |
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| Natural human IgG subclass antibodies to Plasmodium falciparum blood stage antigens
and their relation to malaria resistance in an endemic area of Thailand. |
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| Tangteerawatana, P., Krudsood, S., Chalermrut, K., Looareesuwan, S., and Khusmith, S.
|
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| Department of Microbiology, Faculty of Medicine, Srinakharinwirot University, Bangkok,
Thailand |
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| Abstract: The immunoglobulin G (IgG) subclass antibodies to Plasmodium falciparum blood stage
antigens in the sera of 181 individuals living in malaria endemic area in Kanchanaburi Province, western Thailand, were determined by enzyme-linked
immunosorbent assay (ELISA). In this study, IgG3 and IgG1 were shown to be the predominant subclasses. Generally, IgG2 were coexpressed with IgG1
and IgG3 while IgG4 was found to coexpress with other three IgG subclasses. The levels of specific IgG1, IgG2, and IgG3 increased significantly with age
(r = 0.295, p = 0.000; r = 0.416, p = 0.000; r = 0.320, p = 0.000, respectively). The data indicate that the higher antibody production required continuous
stimulation under natural condition. Furthermore, the levels of specific IgG1, IgG2 and IgG3 increased in immune individuals without clinical malaria,
reported in adolescents and adults, were associated with malaria resistance. Similar results were found in children with different patterns of IgG
subclasses in which the specific IgG2 and IgG3, but not IgG1 was related to resistance |
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| Published in:Southeast Asian J.Trop.Med.Public Health 32[2], 247-254. 2001. |
