| 2002 |
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| Lack of association between interleukin-10 gene promoter polymorphism, -1082G/A, and
severe malaria in Thailand. |
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| Ohashi, J., Naka, I., Patarapotikul, J., Hananantachai, H., Looareesuwan, S., and Tokunaga, K.
|
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| Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Japan
juno@mu-tokyoacjp |
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| Abstract: Interleukin-10 (IL-10) is an important cytokine in the down-regulation of inflammatory
responses, and it has been reported that a low plasma concentration of IL-10 is associated with severe anemia and cerebral malaria in Plasmodium
falciparum infections. The IL-10 gene is located on chromosome 1q31-32, and a promoter polymorphism (-1082G/A) is known to affect IL-10 protein
production. In order to examine the possible association of the -1082G/A polymorphism with the severity of malaria, we studied 203 mild malaria, 164
non-cerebral severe malaria, and 109 cerebral malaria patients living in northwest Thailand. The genotyping was performed by a fluorescence resonance
energy transfer (FRET) method. The frequencies of a major allele -1082A in mild malaria, in non-cerebral severe malaria, and in cerebral malaria patients
were 92.6%, 92.1%, and 92.7% respectively. Our results showed no significant association of the -1082G/A polymorphism with the severity of
malaria |
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| Published in:Southeast Asian J.Trop.Med.Public Health 33 Suppl 3, 5-7. 2002. |
