| 2003 |
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| Genetic variants of beta-globin gene in Thai malaria patients. |
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| Naka, I., Ohashi, J., Patarapotikul, J., Hananantachai, H., Looareesuwan, S., and Tokunaga, K.
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| Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo,
Japan |
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| Abstract: Hemoglobin E (E26K variant of beta-globin gene) causing hemoglobinopathy is
commonly observed in parts of Thailand, regardless of the hematologic disadvantage of the homozygotes. In order to detect further variants of the beta-
globin gene, we performed variation screening for exon 1 of the beta-globin gene in 64 adult patients with P. falciparum malaria, living in northwest
Thailand. We identified E26K and two novel variants, 59C>T and IVS+1G>T. IVS+1G>T lies on the splice donor site, and a substitution of A for G at the
same site (IVS+1G>A) is known to be linked to beta-thalassemia. Thus, the biological significance of IVS+1G>T and its association with malarial infection
should be clarified in future studies |
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| Published in:Southeast Asian J.Trop.Med.Public Health 34 Suppl 2, 29-31. 2003. |
