| 2003 |
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| A single-nucleotide substitution from C to T at position -1055 in the IL-13 promoter is
associated with protection from severe malaria in Thailand. |
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| Ohashi, J., Naka, I., Patarapotikul, J., Hananantachai, H., Looareesuwan, S., and Tokunaga, K.
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| Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo,
Japan juno@mu-tokyoacjp |
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| Abstract: We examined a possible association of single-nucleotide polymorphisms (SNPs) in the
promoters of IL-3, IL-4, and IL-13 genes on the 5q31-33, IL-3 -16T>C, IL-4 -590T>C, and IL-13 -1055C>T, with severity of malaria in 361 adult malaria
patients in Thailand. The IL-13 -1055T allele showed a significant association with protection from severe malaria (OR 0.51, 95% CI 0.32-0.80; P=0.0032
by the chi(2) test), while allele frequencies of IL-3 -16T>C and IL-4 -590T>C were not statistically different between mild and severe malaria patients. An IL
-13 -1055C>T has been reported to alter the regulation of IL-13 production. Thus, IL-13 -1055T may show resistance to severe malaria through the
alteration of IL-13 production |
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| Published in:Genes Immun. 4[7], 528-531. 2003. |
