| 2004 |
| |
| A survey of the Th2R and Th3R allelic variants in the circumsporozoite protein gene of P.
falciparum parasites from western Thailand. |
| |
| Kumkhaek, C., Phra-ek, K., Singhasivanon, P., Looareesuwan, S., Hirunpetcharat, C., Brockman,
A., Gruner, A. C., Lebrun, N., Renia, L., Nosten, F., Snounou, G., and Khusmith, S. |
| |
| Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University,
Bangkok, Thailand |
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| Abstract: Allelic variation in the Plasmodium falciparum circumsporozoite protein (CS) gene has
been determined by sequencing the immunodominant T-cell epitopes, Th2R and Th3R, from 95 isolates from two malaria-endemic areas in the west of
Thailand. Comparison with a reference sequence revealed only non-synonymous point mutations in the two epitope regions. Point mutations were found
outside these epitopes in a minority of samples, and all but four were also non-synonymous. A relatively high number of variants, 11 Th2R and 9 Th3R,
were detected and comprised some that had not been previously observed. However, the Th2R*05 and the Th3R*01 allelic variants predominated, as
they were found in more than 70% of the 101 sequences obtained |
| |
| Published in:Southeast Asian J.Trop.Med.Public Health 35[2], 281-287. 2004. |
