| 2005 |
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| A functional polymorphism in the IL1B gene promoter, IL1B -31C>T, is not associated
with cerebral malaria in Thailand. |
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| Ohashi, J., Naka, I., Doi, A., Patarapotikul, J., Hananantachai, H., Tangpukdee, N.,
Looareesuwan, S., and Tokunaga, K. |
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| Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, 7-3-1
Hongo, Tokyo 113-0033, Japan juno-tky@uminacjp |
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| Abstract: BACKGROUND: IL-1beta and IL-1RA levels are higher in the serum of cerebral malaria
patients than in patients with mild malaria. Recently, the level of IL1B expression was reported to be influenced by a polymorphism in the promoter of IL1,
IL1B -31C>T. METHODS: To examine whether polymorphisms in IL1B and IL1RA influence the susceptibility to cerebral malaria, IL1B -31C>T, IL1B
3953C>T, and IL1RA variable number of tandem repeat (VNTR) were analysed in 312 Thai patients with malaria (109 cerebral malaria and 203 mild
malaria patients). RESULTS: In this population, IL1B -31C>T and IL1RA VNTR were detected, while IL1B 3953C>T (i.e., IL1B 3953T) was not observed in
the polymorphism screening for 32 patients. Further analyses for IL1B -31C>T and IL1RA VNTR in 110 cerebral malaria and 206 mild malaria patients
showed no significant association of these polymorphisms with cerebral malaria. CONCLUSION: The present results suggest that IL1B -31C>T and
IL1RA VNTR polymorphisms do not play a crucial role in susceptibility or resistance to cerebral malaria |
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| Published in:Malar.J. 4, 38. 2005. |
