| 2008 |
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| Linkage disequilibrium structure of the 5q31-33 region in a Thai
population. |
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| Nuchnoi, P., Ohashi, J., Naka, I., Nacapunchai, D., Tokunaga, K., Nishida, N., and Patarapotikul,
J. |
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| Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand |
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| Abstract: A number of loci related to the immune response are located on human chromosomal
region 5q31-33, and polymorphisms in this region have been reported to be associated with autoimmune and infectious diseases. In Southeast Asian
populations, no systematic survey with dense SNP markers has been performed for the 5q31-33 region. In this study, the LD and haplotype structures for
a 472-kb region on 5q31 were investigated in a Thai population to provide useful information for association studies. In addition, the LD structure in Thais
was compared with that of the CHB and JPT HapMap populations (CHB + JPT) to evaluate the transferability of tagging SNPs from CHB + JPT for
Thais. We show that the minor allele frequency, pattern of LD block, and genetic structure in the 5q31-33 region were highly concordant between Thais
and CHB + JPT. A high transferability of tagging SNPs from CHB + JPT for Thais was observed. Our results suggest that tagging SNPs from CHB + JPT
(Northeast Asians) can efficiently capture common variants in Southeast Asians, and that the HapMap data are useful for association studies in
Southeast Asian populations |
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| Published in:J.Hum.Genet. 53[9], 850-856. 2008. |
