Dr. Chonlatip Pipattanaboon CEAR Researcher

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chonlatip.pip@mahidol.ac.th
+66 (0) 2354-9100-4, +66 (0) 2306-9100-9 ext. 2045

Background

Dr. Chonlatip Pipattanaboon carries out research at the Center of Excellence for Antibody Research (CEAR). Her research focuses on the use of monoclonal antibodies in dengue virus research. She has a particular interest in antibody production, characterization, and engineering against the dengue virus and Flaviviruses in general. In addition to her work with CEAR, Dr. Chonlatip also collaborates closely with the research group at Research Institute for Microbial Diseases (RIMD) and the BIKEN Endowed Centre for Vaccine Development, Osaka University, Japan.

Affiliations

Center of Excellence for Antibody Research (CEAR)

Research

Dr. Chonlatip Pipattanaboon is involved in a number of research projects. The Faculty of Tropical Medicine is funding her work in epitope mapping of neutralizing human monoclonal antibodies against dengue virus using escape mutant strategy. Another project, funded by the National Research Council of Thailand, involves development of human monoclonal antibodies against dengue infection by reducing antibody-dependent enhancement (ADE) reactivity. A third project, funded by the Thailand Research Fund involves engineering the Fc region of cross-neutralizing human IgG antibodies against dengue virus.

Her work has led to numerous awards, including the Gold Medal Award, 2014 TAIPEI INT’L INVENTION SHOW & TECHNOMART, Taipei, Taiwan; the 2014 Honor of Invention, from the World Invention Intellectual Property Association (WIIPA); the 2014 Leading Innovation Award, from the International Intellectual Property Forum (IIPF); the 2014; the 2014 Excellent Invention Award, from the International Intellectual Property Industry Association (TIIIA); and the Outstanding Research Award in Medical Sciences in 2013 from the National Research Council of Thailand (NRCT). In addition, Dr. Chonlatip shares a patent for an antigenic peptide derived from dengue virus.

Qualifications

2013 Ph.D. (Tropical Medicine) Tropical Medicine, Mahidol University
2007 B.Sc. (Biology, 1st class Honors) Silpakorn University

Research Areas

  • Antibody production and characterization
  • Gene expression and engineering
  • Epitope mapping
  • Virology and Immunology of dengue virus

Publications

The full list of publications by Dr. Chonlatip Pipattanaboon can be seen on NCBI.

Selected Publications

Molecular genetic characterization of rabies virus glycoprotein gene sequences from rabid dogs in Bangkok and neighboring provinces in Thailand, 2013-2014
Benjathummarak S, Fa-Ngoen C, Pipattanaboon C, Boonha K, Ramasoota P, Pitaksajjakul P.
Arch Virol. 2016 Feb 18.

Antibody germline characterization of cross-neutralizing human IgGs against 4 serotypes of dengue virus
Pitaksajjakul P, Benjathummarak S, Pipattanaboon C, Wongwit W, Tamaki Okabayashi T , Kuhara M, Misaki R, Fujiyama K, Ramasoota P.
Biochem Biophys Res Commun. 2014; pii: S0006-291X(14)00410-0.

Cross-reactivity of human monoclonal antibodies generated with peripheral blood lymphocytes from dengue patients with Japanese encephalitis virus
Pipattanaboon C, Sasaki T, Nishimura M, Setthapramote C, Pitaksajjakul P, Leaungwutiwong P, Limkittikul K, Puiprom O, Sasayama M, Chaichana P, Okabayashi T, Kurosu T, Ono KI, Ramasoota P, Ikuta K
Biologics: Targets and Therapy 2013:7;175-186.

Dengue virus neutralization and antibody-dependent enhancement activities of human monoclonal antibodies derived from dengue patients at acute phase of secondary infection
Sasaki T, Setthapramote C, Kurosu T, Nishimura M, Asai A, Omokoko MD, Pipattanaboon C, Pitaksajjakul P, Limkittikul K, Subchareon A, Chaichana P, Okabayashi T, Hirai I, Leaungwutiwong P, Misaki R, Fujiyama K, Ono K, Okuno Y, Ramasoota P, Ikuta K.
Antiviral Res. 2013 Jun; 98(3): 423-31.

Limited cross-reactivity of mouse monoclonal antibodies against dengue virus capsid protein among four serotypes
Noda M, Yamashita A, Masrinoul P, Punkum C, Pipattanaboon C, Setthapramote C, Sasaki T, Sasayama M, Kurosu T, Ikuta K, Ramasoota P, Okabayashi T.
Biologics Target & Therapies.2012; 6: 409-16.

Human monoclonal antibodies to neutralize all dengue-virus serotypes using lymphocytes from patients at acute phase of the secondary infection
Setthapramote C, Sasaki T, Puiprom O, Limkittikul K, Pitaksajjakul P, Pipattanaboon C, Sasayama M, Leuangwutiwong P, Phumratanaprapin W, Chamnachanan S, Kusolsuk T, Jittmittraphap A, Asai A, Arias JF, Hirai I, Kuhara M, Okuno Y, Kurosu T, Ramasoota P, Ikuta K.
Biochem Biophys Res Commun. 2012; 423: 867-872.