{"id":374,"date":"2022-01-12T08:08:59","date_gmt":"2022-01-12T08:08:59","guid":{"rendered":"http:\/\/10.11.101.29\/cear\/?page_id=374"},"modified":"2022-01-18T04:28:55","modified_gmt":"2022-01-18T04:28:55","slug":"cear-output-patent","status":"publish","type":"page","link":"http:\/\/10.11.101.29\/cear\/cear-output-patent\/","title":{"rendered":"CEAR Output \/ Patent"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"374\" class=\"elementor elementor-374\" data-elementor-settings=\"{&quot;ha_cmc_init_switcher&quot;:&quot;no&quot;}\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-c499723 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c499723\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"aux-parallax-section elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-e20baa1\" data-id=\"e20baa1\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d4e32be elementor-widget elementor-widget-aux_modern_heading\" data-id=\"d4e32be\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"aux_modern_heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<section class=\"aux-widget-modern-heading\">\n            <div class=\"aux-widget-inner\"><h2 class=\"aux-modern-heading-primary\">CEAR output<\/h2><h3 class=\"aux-modern-heading-secondary\"><span class=\"aux-head-highlight\">Center of Excellence for Antibody Research (CEAR)<\/span><\/h3><div class=\"aux-modern-heading-divider\"><\/div><\/div>\n        <\/section>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-89b6b77 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"89b6b77\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"aux-parallax-section elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-09accd4\" data-id=\"09accd4\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f772f0e elementor-widget elementor-widget-text-editor\" data-id=\"f772f0e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<table border=\"1\" cellpadding=\"0\" cellspacing=\"0\" style=\"width:800px;  \">\n\t<tbody>\n\t\t<tr style=\" background-color: coral; \">\n\t\t\t<td style=\"width:85px;  \">\n\t\t\t<p class=\"rteindent1\">Year<\/p>\n\t\t\t<\/td>\n\t\t\t<td style=\"width:387px;\">\n\t\t\t<p>Outstanding achievements<\/p>\n\t\t\t<\/td>\n\t\t\t<td style=\"width:129px;\">\n\t\t\t<p>PI<\/p>\n\t\t\t<\/td>\n\t\t<\/tr>\n\t\t<tr style=\" background-color: #B0C4DE;\">\n\t\t\t<td style=\"width:85px;\">\n\t\t\t<p class=\"rteindent1\">2010<\/p>\n\t\t\t<\/td>\n\t\t\t<td style=\"width:387px;\">\n\t\t\t<p>Center of Excellence for Antibody Research (CEAR) was established with the 60 million baths supported from JICA.<\/p>\n\t\t\t<\/td>\n\t\t\t<td style=\"width:129px;\">\n\t\t\t<p>Dr. Pongrama Ramasoota<\/p>\n\t\t\t<\/td>\n\t\t<\/tr>\n\t\t<tr style=\" background-color: #D3D3D3;\">\n\t\t\t<td style=\"width:85px;\">\n\t\t\t<p class=\"rteindent1\">2013<\/p>\n\t\t\t<\/td>\n\t\t\t<td style=\"width:387px;\">\n\t\t\t<p>The 1<sup>st<\/sup> Neutralizing human monoclonal antibody (NhuMAb) neutralized all 4 serotypes of dengue virus was developed, and tested in challenged monkey. Two patents was issued in 11 countries.<\/p>\n\t\t\t<\/td>\n\t\t\t<td style=\"width:129px;\">\n\t\t\t<p>Dr. Pongrama Ramasoota<\/p>\n\t\t\t<\/td>\n\t\t<\/tr>\n\t\t<tr style=\" background-color: #B0C4DE;\">\n\t\t\t<td style=\"width:85px;\">\n\t\t\t<p>2015-2017<\/p>\n\t\t\t<\/td>\n\t\t\t<td style=\"width:387px;\">\n\t\t\t<p>NhuMAb against dengue virus without causing ADE was developed. (Fc modified NhuMAb)<\/p>\n\t\t\t<\/td>\n\t\t\t<td style=\"width:129px;\">\n\t\t\t<p>Dr. Pannamthip Pitaksajjakul<\/p>\n\t\t\t<\/td>\n\t\t<\/tr>\n\t\t<tr style=\" background-color: #D3D3D3;\">\n\t\t\t<td style=\"width:85px;\">\n\t\t\t<p class=\"rteindent1\">2019<\/p>\n\t\t\t<\/td>\n\t\t\t<td style=\"width:387px;\">\n\t\t\t<p>Licensing contract between BSV Bio-Sciences company and Mahidol University was signed. GMP Production of NhuMAb was done and clinical trials will be performed in 2022-2025.  <\/p>\n\t\t\t<\/td>\n\t\t\t<td style=\"width:129px;\">\n\t\t\t<p>Dr. Pongrama Ramasoota<\/p>\n\t\t\t<\/td>\n\t\t<\/tr>\n\t<\/tbody>\n<\/table>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-89581c4 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"89581c4\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"aux-parallax-section elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-fad3817\" data-id=\"fad3817\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-68b6183 elementor-widget elementor-widget-heading\" data-id=\"68b6183\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Patents<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-86d6484 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"86d6484\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"aux-parallax-section elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-ef86254\" data-id=\"ef86254\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6811300 elementor-widget elementor-widget-text-editor\" data-id=\"6811300\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>Antigenic Peptide Derived From Dengue Virus<\/li><li>Dengue Virus Serotype Neutralizing Antibodies<span style=\"line-height: 1.6em;\"> Patent issue for 9 countries (Australia, India, Indonesia, Lao, Philippine, Singapore, Thailand,<\/span><span style=\"line-height: 1.6em;\"> U.S.A and Vietnam)<\/span><\/li><li><span style=\"line-height: 1.6em;\">Us-patent number 3190-170; Efficient preparation of Human Monoclonal antibody To Neutralize All Serotypes of Dengue Virus Using Peripheral Blood Lymphocytes From Patients.<\/span><\/li><li>Us-patent number 3190-181; Epitope-Based Vaccine With Dengue Virus Domain II Immunogens Derived From The Recognition Region By Dengue Patients\u2019 Peripheral Blood Lymphocyte-Derived Human Monoclonal Antibodies Showing Neutralization of All Four Serotypes Of Dengue Virus<\/li><li><a href=\"\/cear\/sites\/default\/files\/uploads\/1\/Patent-CEAR-2018.pdf\" target=\"_blank\" rel=\"noopener\">Dengue-virus serotype neutralizing antibodies but suppress induction of infection-enhancing antibody Japanese Patent Application PCT\/JP2017\/015384<\/a> <img decoding=\"async\" style=\"opacity: 0.9; width: 25px; height: 25px;\" src=\"\/cear\/sites\/default\/files\/uploads\/1\/icon-pdf.jpg\" alt=\"\" border=\"0\" \/><\/li><li><a href=\"\/cear\/sites\/default\/files\/uploads\/1\/Patent-CEAR-2018-2.pdf\" target=\"_blank\" rel=\"noopener\"><u><strong>\u0e2a\u0e34\u0e17\u0e18\u0e34\u0e1a\u0e31\u0e15\u0e23<\/strong><\/u> \u0e40\u0e23\u0e37\u0e48\u0e2d\u0e07 \u0e42\u0e21\u0e42\u0e19\u0e42\u0e04\u0e25\u0e19\u0e2d\u0e25\u0e41\u0e2d\u0e19\u0e15\u0e34\u0e1a\u0e2d\u0e14\u0e35\u0e2a\u0e33\u0e2b\u0e23\u0e31\u0e1a\u0e27\u0e34\u0e19\u0e34\u0e08\u0e09\u0e31\u0e22\u0e42\u0e23\u0e04\u0e1b\u0e32\u0e01\u0e40\u0e17\u0e49\u0e32\u0e40\u0e1b\u0e37\u0e48\u0e2d\u0e22\u0e41\u0e25\u0e30\u0e27\u0e34\u0e18\u0e35\u0e01\u0e32\u0e23\u0e1c\u0e25\u0e34\u0e15\u0e42\u0e21\u0e42\u0e19\u0e42\u0e04\u0e25\u0e19\u0e2d\u0e25\u0e41\u0e2d\u0e19\u0e15\u0e34\u0e1a\u0e2d\u0e14\u0e35 (\u0e01\u0e33\u0e25\u0e31\u0e07\u0e22\u0e37\u0e48\u0e19\u0e02\u0e2d\u0e2a\u0e34\u0e17\u0e18\u0e34\u0e1a\u0e31\u0e15\u0e23\u0e43\u0e19\u0e1b\u0e23\u0e30\u0e40\u0e17\u0e28\u0e44\u0e17\u0e22) \u0e40\u0e25\u0e02\u0e17\u0e35\u0e48\u0e04\u0e33\u0e02\u0e2d 1601003461)<\/a> <img decoding=\"async\" style=\"opacity: 0.9; width: 25px; height: 25px;\" src=\"\/cear\/sites\/default\/files\/uploads\/1\/icon-pdf.jpg\" alt=\"\" border=\"0\" \/><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>CEAR output Center of Excellence for Antibody Research (CEAR) Year Outstanding achievements PI 2010 Center of Excellence for Antibody Research (CEAR) was established with the 60 million baths supported from JICA. Dr. Pongrama Ramasoota 2013 The 1st Neutralizing human monoclonal antibody (NhuMAb) neutralized all 4 serotypes of dengue virus was developed, and tested in challenged [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-374","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"http:\/\/10.11.101.29\/cear\/wp-json\/wp\/v2\/pages\/374","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/10.11.101.29\/cear\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/10.11.101.29\/cear\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/10.11.101.29\/cear\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"http:\/\/10.11.101.29\/cear\/wp-json\/wp\/v2\/comments?post=374"}],"version-history":[{"count":11,"href":"http:\/\/10.11.101.29\/cear\/wp-json\/wp\/v2\/pages\/374\/revisions"}],"predecessor-version":[{"id":1340,"href":"http:\/\/10.11.101.29\/cear\/wp-json\/wp\/v2\/pages\/374\/revisions\/1340"}],"wp:attachment":[{"href":"http:\/\/10.11.101.29\/cear\/wp-json\/wp\/v2\/media?parent=374"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}