Excellence of Faculty of Tropical Medicine
  Training Courses in Tropical Medicine
  Faculty of Tropical Medicine, Mahidol University  
  The Faculty of Tropical Medicine, Mahidol University, regularly offers international training courses in tropical medicine and short-course trainings in tropical diseases to medical doctors, scientists and health personnel from various countries all over the world. The courses aim to provide participants with an up-to-date knowledge and intensive lessons in tropical medicine, as well as to strengthen the participant’s potential capability in tropical medicine particularly in diagnosis, treatment management, prevention and control. These courses also provide an opportunity for experience-sharing and academic exchange among participants in the international community.

The Faculty of Tropical Medicine is widely accepted as an academic institution emphasizing on research and training in tropical medicine. Both long-term and shot-course trainings are not exclusively offered to participants from the countries located in the tropics, but attendance is also possible for those from other countries in different areas of the world who need such training.

For further information, please contact:
International Relations Office
Email : tmirunit@diamond.mahidol.ac.th
  Clinical trials
  Clinical trials – the number of patients randomised by TROPMED as percentage of all patients randomised worldwide since 1960 is displayed in the image below.  
  Pioneering the use of artemisinin derivatives and, in particular, artemisinin combination treatments (ACTs) for the treatment of falciparum malaria. We have provided a considerable proportion of the biological, economic and clinical basis for the change in global antimalarial treatment recommendations to ACTs. We also have developed a mathematical-economic model of drug resistance which has been influential in guiding international recommendations.  
  Development of an in vivo model of antimalarial drug action, which is now generally accepted and provides a rational basis for assessing drug dosing, duration, choice of combination, assessment of adherence, and resistance selection which are based on identification of the mechanisms of parasite clearance, and extensive comparative PK-PD studies in falciparum and vivax malaria  
  Establishment of the safety profile of artemisinin derivatives, showing that neurotoxicity was determined largely by the pharmacokinetic properties of the individual drugs, and that in detailed pathological and neurophysiological studies there was no evidence for detectable neurotoxicity in humans.  
  Pioneering the conduct of large randomized trials of antimalarial drugs in malaria endemic areas based on pharmacokinetic and pharmacodynamic (PK-PD) principles, which have now been accepted by WHO. A recent overview of all 435 antimalarial drug trials published since 1966 showed that the Wellcome Unit in Thailand was responsible for publishing 9.4% of all antimalarial trials and enrolling 21.7% of all patients (17,955/82,616) enrolled in such studies worldwide.  
  Assessment of the pharmacokinetics, efficacy, and safety of artesunate-mefloquine, artesunate-atovaquone-proguanil, artemether-lumefantrine, and dihydroartemisinin in the treatment of multi-drug resistant falciparum malaria, forming a scientific basis for regional policy recommendations.  
  Identification of the principal mechanism for mefloquine resistance in Plasmodium falciparum (amplification in Pf MDR1), and characterization of the molecular basis of antifol resistance in Plasmodium vivax and its geographic distribution.  
  Discovery of reduced uninfected erythrocyte deformability as a major pathological process in severe falciparum malaria, and characterization of its pathological basis (and identification of possible interventions).  
  Sequestration of parasitized erythrocytes in the microvasculature of vital organs is the central pathological feature of severe falciparum malaria. For the first time, we have visualized and measured sequestration in vivo. We have developed a method for assessing the sequestered biomass based on plasma PfHRP2 measurement.  
Last update: 11 March 2014
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