Research in Hospital for Tropical Diseases

          Apart from our main mission, “provide excellent medical care in the field of tropical medicine”, one of our key missions is “to support a research in the field of tropical medicine”. Our hospital plays a major role as a research ground for clinicians, scientists, residents, nurses, as well as our Ph.D and Master degree students.

          Each year, Hospital for Tropical Diseases supports several types of research/study such as:
                    1. Clinical Trials for example: the efficacy study of new antimalarial medication
                    2. Clinical non-interventional research
                    3. Cohort study 
                    4. Cross sectional study
                    5. Retrospective review
                    6. Laboratory research using specimen from our hospital

          All research conducted in the hospital have the approval from the Ethical Committee of the Faculty of Tropical Medicine and must comply with the highest international standard code of ethics such as the ICH/GCP.

          Some highlight of our publications:
                    2016: Residency in Travel Medicine – A 3-year journey to become a specialist
                    2015: Pharmacokinetic interactions between primaquine and pyronaridine- artesunate
                               in healthy adult Thai subjects
                               Identification of clinical factors associated with severe dengue among Thai adults:
                               a prospective study
                    2014: Clinical Factors for Severity of Plasmodium falciparum Malaria in Hospitalized
                               Adults in Thailand
                    2013: Risk factors of shock in severe falciparum malaria
                    2012: Risk of Potentially Rabid Animal Exposure among Foreign Travelers in SE Asia  

List of publications:

          2016 :

          1) Piyaphanee W, Chanthavanich P. Residency training in travel medicine—a 3-year journey to become a
              specialist. J Travel Med. 2016;23(5). pii: taw041. doi: 10.1093/jtm/taw041.

          2) Phyo AP, Jittamala P, Nosten FH, Pukrittayakamee S, Imwong M, White NJ, Duparc S, Macintyre F, Baker M,
              Möhrle JJ. Antimalarial activity of artefenomel (OZ439), a novel synthetic antimalarial endoperoxide, in patients
              with Plasmodium falciparum and Plasmodium vivax malaria: an open-label phase 2 trial. Lancet Infect Dis
              2016;16(1):61-9. doi: 10.1016/S1473-3099(15)00320-5.

          3) Chairat K, Jittamala P, Hanpithakpong W, Day NP, White NJ, Pukrittayakamee S, Tarning J. Population
              pharmacokinetics of oseltamivir and oseltamivir carboxylate in obese and non-obese volunteers.Br J Clin
              Pharmacol 2016;81(6):1103-12. doi: 10.1111/bcp.12892.

          4) Kumsiri R, Troye-Blomberg M, Pattanapanyasat K, Krudsood S, Maneerat Y. IgE low affinity receptor (CD23)
              expression, Plasmodium falciparum specific IgE and tumor necrosis factor-alpha production in Thai
              uncomplicated and severe falciparum malaria patients. Acta Trop 2016;154:25-33. doi: 10.1016/j.actatropica.

          5) Martínez Vega R, Phumratanaprapin W, Phonrat B, Dhitavat J, Sutherat M, Choovichian V. Differences in Liver
              Impairment Between Adults and Children with Dengue Infection. Am J Trop Med Hyg 2016;9 4(5):1073-9. doi:

          6) Thanachartwet V, Wattanathum A, Oer-areemitr N, Jittmittraphap A, Sahassananda D, Monpassorn C,
              Surabotsophon M, Desakorn V. Diagnostic accuracy of peripheral venous lactate and the 2009 WHO warning
              signs for identifying severe dengue in Thai adults: a prospective observational study. BMC Infect Dis 2016;

          7) Santajit S, Indrawattana N.Mechanisms of Antimicrobial Resistance in ESKAPE Pathogens. Biomed Res Int
              2016;2016:2475067. doi: 10.1155/2016/2475067.

          8) Thanachartwet V, Wattanathum A, Sahassananda D, Wacharasint P, Chamnanchanunt S, Khine Kyaw E,
              Jittmittraphap A, Naksomphun M, Surabotsophon M, Desakorn V. Dynamic Measurement of Hemodynamic
              Parameters and Cardiac Preload in Adults with Dengue: A Prospective Observational Study. PLoS One 2016;
              11(5):e0156135. doi: 10.1371/journal.pone.0156135.


          1) Choovichian V, Chatapat L, Piyaphanee W. A Bubble Turtle: Bullous Contact Dermatitis After a Black Henna
              Tattoo in a Backpacker in Thailand. J Travel Med 2015; 22(4): 287-8.

          2) Kittitrakul C, Lawpoolsri S, Kusolsuk T, Olanwichitwong J, Tangkanakul W, Piyaphanee W. Travelers' Diarrhea
              in Foreign Travelers in Southeast Asia: A Cross-Sectional Study in Bangkok, Thailand. Am J Trop Med Hyg
              2015;93(3): 485-90.

          3) Jittamala P, Pukrittayakamee S, Ashley EA, Nosten F, Hanboonkunupakarn B, Lee SJ, Thana P, Chairat K,
              Blessborn D, Panapipat S, White NJ, Day NP, Tarning J. Pharmacokinetic interactions between primaquine and
              pyronaridine-artesunate in healthy adult Thai subjects. Antimicrob Agents Chemother 2015;59(1):505-13. doi:

          4) Hanboonkunupakarn B, Ashley EA, Jittamala P, Tarning J, Pukrittayakamee S, Hanpithakpong W, Chotsiri P,
              Wattanakul T, Panapipat S, Lee SJ, Day NP, White NJ. Open-Label Crossover Study of Primaquine and
              Dihydroartemisinin-Piperaquine .Antimicrob Agents Chemother 2014;58(12):7340-6. doi: 10.1128/AAC.03704-

          5) Treeprasertsuk S, Kittitrakul C. Liver complication in adult dengue and current management. Southeast Asian J
              Trop Med Public Health 2015;46 Suppl 1:99-107.

          6) Ampawong S, Chaisri U, Viriyavejakul P, Prapansilp P, Grau GE, Turner GD, Pongponratn E. A potential role
              for interleukin-33 and γ-epithelium sodium channel in the pathogenesis of human malaria associated lung
              injury. Malar J 2015; 14:389. doi: 10.1186/s12936-015-0922-x.

          7) Thanachartwet V, Oer-Areemitr N, Chamnanchanunt S, Sahassananda D, Jittmittraphap A, Suwannakudt P,
              Desakorn V, Wattanathum A. Identification of clinical factors associated with severe dengue among Thai adults:
              a prospective study. BMC Infect Dis 2015;15:420. doi: 10.1186/s12879-015-1150-2.

          8) Gautret P, Harvey K, Pandey P, Lim PL, Leder K, Piyaphanee W, Shaw M, McDonald SC, Schwartz E,
              Esposito DH, Parola G; Geosentinel Surveillance Network. Animal-associated exposure to rabies virus among
              travelers. 1997-2012. Emerg Infect Dis 2015; 21(4): 569-77.

          9) Kashino W, Piyaphanee W, Kittitrakul C, Tangpukdee N, Sibunruang S, Lawpoolsri S, Yamashita H,
              Muangnoicharoen S, Silachamroon U, Tantawichian T. Incidence of potential rabbies exposure among
              Japanese expatriates and travelers in Thailand. J Travel Med 2014; 21(3): 163-68.

          10) Piyaphanee, W, Kittitrakul C, Lawpoolsri, Tangkanakul W, Sa-Ngiamsak N, Nasok P, Wongchai S, Ponam T,
              Wichianprasat P, Phumratanaprapin W. Incidence and spectrum of health problems among travelers to Laos. J
              Travel Med 2014; 21(3): 163-8.

Last updated: July 27, 2016
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