{"id":968,"date":"2021-02-16T06:54:39","date_gmt":"2021-02-16T06:54:39","guid":{"rendered":"http:\/\/10.11.101.29\/pediatrics\/?page_id=968"},"modified":"2021-02-16T07:13:50","modified_gmt":"2021-02-16T07:13:50","slug":"research-projects","status":"publish","type":"page","link":"http:\/\/10.11.101.29\/pediatrics\/research-projects\/","title":{"rendered":"Research Projects"},"content":{"rendered":"\t\t
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Research Projects<\/h5>

The current\/ongoing research works include:<\/span><\/h3>

Hand Foot Mouth Disease<\/strong><\/em><\/p>

  • Molecular epidemiological study and mathematical modelling of Hand, foot, and mouth disease (HFMD) in primary school setting in Thailand.<\/li><\/ul>

    Malaria vivax<\/strong><\/em><\/p>

    • An Open Label, Non-comparative,\u00a0 Multicenter Study to Assess the Pharmacokinetics, Safety and Efficacy of Tafenoquine (SB-252263, WR238605) in The Treatment of Pediatric Subjects with\u00a0Plasmodium vivax\u00a0<\/em>Malaria.<\/li><\/ul>

      Dengue<\/strong><\/em><\/p>

      • Phase III, Double-Blind, Randomized, Placebo-Controlled Trial to Investigate the Efficacy, Safety and Immunogenicity of a Tetravalent Dengue Vaccine (TDV) Administered Subcutaneously in Healthy Children Aged 4 \u2013 16 Years Old.<\/p><\/li>

      • Epidemiological study of fever with rash (Zika) in Ampawa district, Samutsongkram province (pilot study)<\/p><\/li><\/ul>

        RSV<\/strong><\/em><\/p>

        • A Phase 2, Double-blind, Placebo-controlled Study to Evaluate the Antiviral Activity, Clinical Outcomes, Safety, Tolerability, and Pharmacokinetic\/ Pharmacodynamic Relationships of Different Doses of JNJ-53718678 in Children \u226528 Days and \u22643 Years of Age With Acute Respiratory Tract Infection Due to Respiratory Syncytial Virus Infection)\u201d<\/li><\/ul>

          Influenza<\/strong><\/em><\/p>

          • A Randomized, Observer-blind, Active Comparator-controlled, Multicenter, Phase 3 Study to Assess the Efficacy, Safety, and Immunogenicity of a Plant-derived Quadrvalent VLP influenza Vaccine in Adults 65 Years of Age and Older<\/p><\/li>

          • A Phase III, Randomized, Observer-blind, Multicenter Study to Evaluate the\u00a0Efficacy, Immunogenicity and Safety of Seqirus\u2019 Cell-Based Quadrivalent Subunit\u00a0Influenza Virus Vaccine (QIVc) Compared to a Non-Influenza Vaccine when Administrated in Healthy Subjects aged 6 Months through 47 Months<\/p><\/li>

          • A Multinational, Comparative Phase III Clinical Trial to Assess the Efficacy (Immunogenicity) and Safety of NBP607-QIV (0.5 mL) (Quadrivalent Inactivated Cell Culture-Derived Influenza Vaccine) in Children Aged 6 to 35 Months<\/p><\/li><\/ul>

            JE vaccine<\/strong><\/em><\/p>

            • Immunogenicity and Safety of Inactivated Vero cell derived Japanese Encephalitis Vaccine in Thai children.<\/li><\/ul>

              \u00a0<\/p>

              The important and complete research works include:<\/strong><\/p>

              Dengue<\/strong><\/em><\/p>

              • Burden of dengue infection in children and adults of Bang Phae district, Ratchaburi province, Thailand (Dengue Serological Survey).<\/p><\/li>

              • A Phase I\/II, Randomized, Observer-Blind, Multicenter Study to Evaluate Immunogenicity and Safety of Four Influenza Vaccines in Healthy Pediatric Subjects 6 to <48 Months of Age (Protocol Number: V58P16).<\/p><\/li>

              • Long-Term Follow-Up of Hospitalized Dengue and Safety in Thai Children Who Were Included in an Efficacy Study of a Tetravalent Dengue Vaccine (CYD57).<\/p><\/li>

              • Association of Host Immune Genetics and Vaccine Efficacy, and Evaluation of Immune Correlates of Risk from the First Proof of Concept Efficacy Study with a Tetravalent Dengue Vaccine) (CYD59).<\/p><\/li>

              • Epidemiological study of dengue infection in children in Ratchaburi Province (RAT0148).<\/p><\/li>

              • Safety and immunogenicity of tetravalent dengue vaccine formulations in healthy Thai children, clinical trial protocol amendment 3 version number 2.0 date 09 August 2004 (DEN06199 amendment 3).<\/p><\/li>

              • Dengue antibodies level and incidence of dengue infection in pre-school-aged children (Data analysis) (DEN0448).<\/p><\/li>

              • Socio-behavioral focus group study of community knowledge and attitudes related to the dengue fever and an up-coming dengue vaccination in Ratchaburi, Thailand.<\/p><\/li>

              • Study of dengue antibody in infants.<\/p><\/li><\/ul>

                Rabies<\/strong><\/em><\/p>

                • Evaluation of long-term-immunity against rabies in children vaccinated with Purified Chick Embryo Cell Rabies Vaccine (Rabipur) in different pre-exposure regimens and boosted after one year.<\/p><\/li>

                • FavirabTM<\/sup>\u00a0post prescription event monitoring.<\/p><\/li>

                • Immunogenicity and safety of PVRV postexposure vaccination in Thai children.<\/p><\/li>

                • Long term rabies antibody profiles in children after id and im administration of purified Vero cell rabies vaccine pre-exposure vaccination and effect of booster doses.<\/p><\/li>

                • Early immune response to multi-sites intramuscular injection of purified Vero cell rabies vaccine (PVRV) for rabies post-exposure treatment.<\/p><\/li>

                • A phase II, pilot, randomized, open-label, single-center study to evaluate immunogenicity, safety and booster response of 3 full intramuscular doses versus 3 half intramuscular dose versus 3 intradermal doses versus 2 intradermal doses of PCEC rabies vaccine (Rabipur) administered concomitantly with Japanese encephalitis vaccine as a pre-exposure regimen in 12 to 18 months old toddlers in Thailand.<\/p><\/li><\/ul>

                  Influenza<\/strong><\/em><\/p>

                  • A Phase III, Stratified, Randomized, Observer Blind, Controlled, Multicenter Clinical Study to Evaluate the Safety, Immunogenicity and Efficacy of an Adjuvanted Quadrivalent Subunit Influenza Virus Vaccine Compared to Non-Adjuvanted Comparator Influenza Vaccine in Children >6 to <72 Months of Age (Protocol Number: V118_05).<\/p><\/li><\/ul>

                    JE vaccine<\/strong><\/em><\/p>

                    • The study of immunogenicity and adverse reaction of JE vaccine (liquid form) Beijing strain produced by the Government Pharmaceutical Organization of Thailand in Thai children.<\/p><\/li><\/ul>

                      Parasitic infection<\/strong><\/em><\/p>

                      • Albendazole efficacy in reducing intestinal parasites, improving nutritional, physical status and intelligence in Thai school children infected with common geohelminths.<\/p><\/li><\/ul>

                        Malaria<\/strong><\/em><\/p>

                        • A randomized comparative trial with suppositories artesunate plus mefloquine and oral artesunate plus mefloquine in uncomplicated symptomatic falciparum malaria in children in Thailand.<\/p>

                          Clinical trial and pharmacokinetic of artesunate suppositories in Thai children with acute uncomplicated falciparum malaria.<\/p><\/li><\/ul>

                          Other Vaccine<\/strong><\/em><\/p>

                          • Safety, tolerability and immunogenicity of the acellular pertussis vaccine combined with diphtheria and tetanus toxoid (DtaP).<\/p><\/li>

                          • Efficacy, safety and tolerability of Tiorfan in the treatment of acute diarrhea in children.<\/p><\/li><\/ul><\/div><\/div>\n <\/section>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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                            Research Projects The current\/ongoing research works include: Hand Foot Mouth Disease Molecular epidemiological study and mathematical modelling of Hand, foot, and mouth disease (HFMD) in primary school setting in Thailand. Malaria vivax An Open Label, Non-comparative,\u00a0 Multicenter Study to Assess the Pharmacokinetics, Safety and Efficacy of Tafenoquine (SB-252263, WR238605) in The Treatment of Pediatric Subjects […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-968","page","type-page","status-publish","hentry"],"yoast_head":"\nResearch Projects - Department of Tropical Pediatrics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/10.11.101.29\/pediatrics\/research-projects\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research Projects - Department of Tropical Pediatrics\" \/>\n<meta property=\"og:description\" content=\"Research Projects The current\/ongoing research works include: Hand Foot Mouth Disease Molecular epidemiological study and mathematical modelling of Hand, foot, and mouth disease (HFMD) in primary school setting in Thailand. 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