Dr. Kesinee Chotivanich Professor of Clinical Tropical Medicine

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kesinee.cho@mahidol.ac.th
+66 (2) 644-4541

Background

Professor of Clinical Tropical Medicine Dr. Kesinee Chotivanich’s background is in pathobiology with particular expertise in cell and tissue culture and the pharmacodynamics of antimalarial drugs. Dr. Chotivanich has been working on two main areas of research: the pathophysiology of malaria infections, and detection of anti-malarial resistance parasites. The method of identification of artemisinin resistance P. falciparum was firstly developed in her lab. She has published over 100 publications, many of which are leading research achievements in the field of malaria studies, such as detection of artemisinin resistance in P. falciparum, and transmission-blocking activities of antimalarial drugs.

Affiliations

Department of Clinical Tropical Medicine

Research

Dr. Kesinee Chotivanich is the Principle Investigator on two ongoing projects: one through a grant from the Newton Fund - National Science and Technology Development Agency (NSTDA) – Medical Research Council (MRC), which is entitled “Preventing the transmission of artemisinin resistant falciparum malaria” and is focused on investigating the effects of antimalarial drugs on the gametocyte of P. falciparum. Her other project “Assessing artemisinin resistance parasite in vitro” is funded by MORU - Wellcome Trust of Great Britain and is aimed at the development of feasible and sensitive methods for detection of artemisinin-resistant parasites. In addition, she is PI and co-investigator in several university-research groups, multicenter studies and on national and international grants. Currently Dr. Chotivanich is involved in developing new methods of assessing gametocyte resistance to artemisinin derivatives and susceptibility of gametocytes to in vitro antimalarial drugs. For example, after identifying resistant parasites, her lab screens and tests new drugs or compounds that might be used as new candidates for multidrug-resistant parasites with the hope of improving standards and procedures of management and treatment for malaria patients.

Qualifications

2000 Postgraduate, Malaria studies MORU, Tropical Medicine Research Programme
1998 Pathobiology Ph.D. Faculty of Science, Mahidol University, Thailand
1995 Pathobiology M.Sc. Faculty of Science, Mahidol University, Thailand
1992 Nursing Science B.Sc. Ramathibodi Hospital, Mahidol University, Thailand

Research Areas

  • Pharmacodynamics of antimalarial drugs
  • Detection of artemisinin resistance
  • Pathophysiology of malaria

Publications

A complete list of publications by Dr. Kesinee Chotivanich can be seen on NCBI and other scientific search engines.

Selected Publications

Laboratory Detection of Artemisinin-Resistant Plasmodium falciparum.
Kesinee Chotivanich, Rupam Tripura, Debashish Das, Poravuth Yi, Nicholas P. J. Day, Sasithon Pukrittayakamee, Char Meng Chuor, Duong Socheat, Arjen M. Dondorp, Nicholas J. White
Antimicrob Agents Chemother. 2014 June; 58(6): 3157–3161.

Plasmodium vivax Adherence to Placental Glycosaminoglycans.
Kesinee Chotivanich, Rachanee Udomsangpetch, Rossarin Suwanarusk, Sasithon Pukrittayakamee, Polrat Wilairatana, James G. Beeson, Nicholas P. J. Day, Nicholas J. White
PLoS One. 2012; 7(4): e34509.

In vitro Anti-Malarial Drug Susceptibility of Temperate Plasmodium vivax from Central China
Feng Lu, Qi Gao, Kesinee Chotivanich, Hui Xia, Jun Cao, Rachanee Udomsangpetch, Liwang Cui, Jetsumon Sattabongkot
Am J Trop Med Hyg. 2011 August 1; 85(2): 197–201.

Transmission-Blocking Activities of Quinine, Primaquine, and Artesunate.
Kesinee Chotivanich, Jetsumon Sattabongkot, Rachanee Udomsangpetch, Sornchai Looareesuwan, Nicholas P. J. Day, Russell E. Coleman, Nicholas J. White
Antimicrob Agents Chemother. 2006 June; 50(6): 1927–1930.

In vitro efficacy of antimalarial drugs against Plasmodium vivax on the western border of Thailand
Chotivanich K, Udomsangpetch R, Chierakul W, Newton PN, Ruangveerayuth R, Pukrittayakamee S, Looareesuwan S, White NJ.
Am J Trop Med Hyg. 2004 Apr;70(4):395-7.

Central role of the spleen in malaria parasite clearance.
Chotivanich K, Udomsangpetch R, McGready R, Proux S, Newton P, Pukrittayakamee S, Looareesuwan S, White NJ.
Infect Dis. 2002 May 15;185(10):1538-41.