{"id":1917,"date":"2024-10-21T03:21:13","date_gmt":"2024-10-21T03:21:13","guid":{"rendered":"http:\/\/10.11.101.25\/wordpress\/vivax\/?p=1917"},"modified":"2024-10-28T07:51:43","modified_gmt":"2024-10-28T07:51:43","slug":"using-humanized-mouse-model-vivo-study-plasmodium","status":"publish","type":"post","link":"http:\/\/10.11.101.25\/wordpress\/vivax\/2024\/10\/21\/using-humanized-mouse-model-vivo-study-plasmodium\/","title":{"rendered":"Using humanized mouse model for in vivo study of Plasmodium vivax"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"1917\" class=\"elementor elementor-1917\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1f7696b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1f7696b\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"aux-parallax-section elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-97cdb22\" data-id=\"97cdb22\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f8a86ce elementor-widget elementor-widget-heading\" data-id=\"f8a86ce\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\"><a href=\"http:\/\/10.11.101.25\/wordpress\/vivax\/research\/\">\u00ab Research Spotlight  |  Drug &amp; Vaccine Development<\/a><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8cd0e7c elementor-widget elementor-widget-heading\" data-id=\"8cd0e7c\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Using humanized mouse model for in vivo study of Plasmodium vivax<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d673214 elementor-widget elementor-widget-text-editor\" data-id=\"d673214\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>28th February, 2018, <a href=\"http:\/\/10.11.101.25\/wordpress\/vivax\/wanlapa-roobsoong\/\">Dr. Wanlapa Roobsoong<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-8a8929e elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"8a8929e\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"aux-parallax-section elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-6009c6e\" data-id=\"6009c6e\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0adcc04 elementor-widget elementor-widget-image\" data-id=\"0adcc04\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"800\" height=\"332\" src=\"http:\/\/10.11.101.25\/wordpress\/vivax\/wp-content\/uploads\/sites\/5\/2024\/10\/research-spotlight-humanised_mice.jpg\" class=\"attachment-full size-full wp-image-1919\" alt=\"\" srcset=\"http:\/\/10.11.101.25\/wordpress\/vivax\/wp-content\/uploads\/sites\/5\/2024\/10\/research-spotlight-humanised_mice.jpg 800w, http:\/\/10.11.101.25\/wordpress\/vivax\/wp-content\/uploads\/sites\/5\/2024\/10\/research-spotlight-humanised_mice-200x83.jpg 200w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-074a8c3 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"074a8c3\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"aux-parallax-section elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7cf8e11\" data-id=\"7cf8e11\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-08527db elementor-widget elementor-widget-text-editor\" data-id=\"08527db\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"col-md-10 src-styles----single-story-module---news_article_main---27R5y\"><div data-reactid=\"84\"><p>To date, the unavailability of the in vitro continuous culture of\u00a0<em>P. vivax<\/em>\u00a0imposing major obstacle for the study of any stages of the life cycle of this parasite. The routine studies of\u00a0<em>P. vivax<\/em>\u00a0solely depend on the variable clinical isolates obtain directly from patients. Humanized mouse model engrafted with human hepatocytes has been successfully used to study the complete life cycle of\u00a0<em>P. falciparum<\/em>. The use of humanized mouse model to study P. vivax would constitute a major breakthrough and revolutionized the way that this unique parasite can be studied in laboratory.<\/p><p>Both liver stage schizont and hypnozoite have been observed. Moreover reactivation of the hypnozoite has been observed. The\u00a0<em>in vivo<\/em>\u00a0study of\u00a0<em>P. vivax *using humanized mouse model engrafted with human hepatocyte is the research collaboration between MVRU and Dr. Sebastian from CIDR, and MVRU and Prof. Osamu Kaneko from Nagasaki university. There are 2 humanized mouse models that effectively used for in vivo study of *P. vivax<\/em>\u00a0at MVRU, FRG-NOD and PXB mice. Both models support liver stage development and liver-to-blood stage transition of\u00a0<em>P. vivax<\/em>\u00a0which revolutionized the way that this parasite can be studied in laboratory. By injecting\u00a0<em>P. vivax<\/em>\u00a0sporozoites through tail vein, they can invade and develop inside the engrafted human hepatocytes with both active and dormant forms (hypnozoite) have been observed. In addition, by injecting human young red blood cells to catch up free merozoites that released from the liver, tightly synchronized blood stage can be obtained. This has opened a wide opportunity to study in vivo drug and vaccine\u2019s efficacy against liver stage and blood stage of\u00a0<em>P. vivax<\/em>.<\/p><p>During malaria elimination era, multiple measures and stringent control strategies are needed in order to completely eliminate malaria. One of the big challenge to eradicate\u00a0<em>P. vivax<\/em>\u00a0is the hypnozoite (dormant form that stay in the liver) which can cause relapse at any time after clinical malaria episodes. The drug that target the hypnozoites would help to protect patients from relapse. Beside primaquine and tefenoquine, there is no new drugs available in the pipeline. The use of humanized mouse model to study\u00a0<em>P. vivax<\/em>\u00a0has constituted a major breakthrough and revolutionized the way to test drug and vaccine\u2019s efficacy in laboratory.<\/p><\/div><div class=\"src-styles----single-story-module---publications_section---TODK9\" data-reactid=\"85\">\u00a0<\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-9e5e302 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"9e5e302\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"aux-parallax-section elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-cb46ff7\" data-id=\"cb46ff7\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-85a0026 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"85a0026\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"aux-parallax-section elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-4f7ee76\" data-id=\"4f7ee76\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d75f34b elementor-widget elementor-widget-text-editor\" data-id=\"d75f34b\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h4 data-reactid=\"102\">Key Information<\/h4><ul data-reactid=\"103\"><li data-reactid=\"104\"><h5 data-reactid=\"105\">Key MVRU Researchers:<\/h5><ul class=\"src-styles----single-story-module---researchers---1mWI6\" data-reactid=\"106\"><li data-reactid=\"107\"><a href=\"http:\/\/10.11.101.25\/wordpress\/vivax\/wanlapa-roobsoong\/\" data-reactid=\"108\">Dr.\u00a0Wanlapa Roobsoong<\/a><\/li><li data-reactid=\"112\"><a href=\"http:\/\/10.11.101.25\/wordpress\/vivax\/wang-nguitragool\/\" data-reactid=\"113\">Assoc. Prof. Dr.\u00a0Wang Nguitragool<\/a><\/li><\/ul><\/li><li data-reactid=\"117\"><h5 data-reactid=\"118\">In collaboration with:<\/h5><ul data-reactid=\"119\"><li data-reactid=\"120\">Sureemas Buates ,\u00a0Mahidol university<\/li><li data-reactid=\"124\">Eun-Taek Han,\u00a0Professor,\u00a0Kangwon National University<\/li><\/ul><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-87b77dc elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"87b77dc\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"aux-parallax-section elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-2a45b91\" data-id=\"2a45b91\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b2c47f2 elementor-widget elementor-widget-heading\" data-id=\"b2c47f2\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Funded by:<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-2141dca elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2141dca\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"aux-parallax-section elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-93b7aa6\" data-id=\"93b7aa6\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-664b481 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"664b481\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"aux-parallax-section elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-72a319d\" data-id=\"72a319d\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a6cdb33 elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"a6cdb33\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"800\" height=\"800\" src=\"http:\/\/10.11.101.25\/wordpress\/vivax\/wp-content\/uploads\/sites\/5\/2024\/09\/USA.png\" class=\"attachment-full size-full wp-image-835\" alt=\"\" srcset=\"http:\/\/10.11.101.25\/wordpress\/vivax\/wp-content\/uploads\/sites\/5\/2024\/09\/USA.png 800w, http:\/\/10.11.101.25\/wordpress\/vivax\/wp-content\/uploads\/sites\/5\/2024\/09\/USA-300x300.png 300w, http:\/\/10.11.101.25\/wordpress\/vivax\/wp-content\/uploads\/sites\/5\/2024\/09\/USA-150x150.png 150w, http:\/\/10.11.101.25\/wordpress\/vivax\/wp-content\/uploads\/sites\/5\/2024\/09\/USA-768x768.png 768w, http:\/\/10.11.101.25\/wordpress\/vivax\/wp-content\/uploads\/sites\/5\/2024\/09\/USA-200x200.png 200w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"aux-parallax-section elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-963144b\" data-id=\"963144b\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f88dd4c elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"f88dd4c\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"2121\" height=\"787\" src=\"http:\/\/10.11.101.25\/wordpress\/vivax\/wp-content\/uploads\/sites\/5\/2024\/09\/MMV.jpg\" class=\"attachment-full size-full wp-image-831\" alt=\"\" srcset=\"http:\/\/10.11.101.25\/wordpress\/vivax\/wp-content\/uploads\/sites\/5\/2024\/09\/MMV.jpg 2121w, http:\/\/10.11.101.25\/wordpress\/vivax\/wp-content\/uploads\/sites\/5\/2024\/09\/MMV-1536x570.jpg 1536w, http:\/\/10.11.101.25\/wordpress\/vivax\/wp-content\/uploads\/sites\/5\/2024\/09\/MMV-2048x760.jpg 2048w, http:\/\/10.11.101.25\/wordpress\/vivax\/wp-content\/uploads\/sites\/5\/2024\/09\/MMV-200x74.jpg 200w\" sizes=\"(max-width: 2121px) 100vw, 2121px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"aux-parallax-section elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-80f1e6b\" data-id=\"80f1e6b\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b55e2ba elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"b55e2ba\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"2560\" height=\"862\" src=\"http:\/\/10.11.101.25\/wordpress\/vivax\/wp-content\/uploads\/sites\/5\/2024\/09\/HIH-national-scaled.jpg\" class=\"attachment-full size-full wp-image-829\" alt=\"\" srcset=\"http:\/\/10.11.101.25\/wordpress\/vivax\/wp-content\/uploads\/sites\/5\/2024\/09\/HIH-national-scaled.jpg 2560w, http:\/\/10.11.101.25\/wordpress\/vivax\/wp-content\/uploads\/sites\/5\/2024\/09\/HIH-national-1536x517.jpg 1536w, http:\/\/10.11.101.25\/wordpress\/vivax\/wp-content\/uploads\/sites\/5\/2024\/09\/HIH-national-2048x690.jpg 2048w, http:\/\/10.11.101.25\/wordpress\/vivax\/wp-content\/uploads\/sites\/5\/2024\/09\/HIH-national-200x67.jpg 200w\" sizes=\"(max-width: 2560px) 100vw, 2560px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-91c0e97 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"91c0e97\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"aux-parallax-section elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-e7665a2\" data-id=\"e7665a2\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5f79d85 elementor-widget elementor-widget-heading\" data-id=\"5f79d85\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Gallery<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-03363ba elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"03363ba\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"aux-parallax-section elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-48e8138\" data-id=\"48e8138\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-3149def elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3149def\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"aux-parallax-section elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-ff3b650\" data-id=\"ff3b650\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0e33839 elementor-widget elementor-widget-image\" data-id=\"0e33839\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"324\" height=\"258\" src=\"http:\/\/10.11.101.25\/wordpress\/vivax\/wp-content\/uploads\/sites\/5\/2024\/10\/Humanised_mice_gal_1.jpg\" class=\"attachment-full size-full wp-image-2194\" alt=\"\" srcset=\"http:\/\/10.11.101.25\/wordpress\/vivax\/wp-content\/uploads\/sites\/5\/2024\/10\/Humanised_mice_gal_1.jpg 324w, http:\/\/10.11.101.25\/wordpress\/vivax\/wp-content\/uploads\/sites\/5\/2024\/10\/Humanised_mice_gal_1-200x159.jpg 200w\" sizes=\"(max-width: 324px) 100vw, 324px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"aux-parallax-section elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-9df7112\" data-id=\"9df7112\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f07e453 elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"f07e453\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"324\" height=\"258\" src=\"http:\/\/10.11.101.25\/wordpress\/vivax\/wp-content\/uploads\/sites\/5\/2024\/10\/Humanised_mice_gal_2.jpg\" class=\"attachment-full size-full wp-image-2195\" alt=\"\" srcset=\"http:\/\/10.11.101.25\/wordpress\/vivax\/wp-content\/uploads\/sites\/5\/2024\/10\/Humanised_mice_gal_2.jpg 324w, http:\/\/10.11.101.25\/wordpress\/vivax\/wp-content\/uploads\/sites\/5\/2024\/10\/Humanised_mice_gal_2-200x159.jpg 200w\" sizes=\"(max-width: 324px) 100vw, 324px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>\u00ab Research Spotlight | Drug &amp; Vaccine Development Using humanized mouse model for in vivo study of Plasmodium vivax 28th February, 2018, Dr. Wanlapa Roobsoong To date, the unavailability of the in vitro continuous culture of\u00a0P. vivax\u00a0imposing major obstacle for the study of any stages of the life cycle of this parasite. The routine studies [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":1919,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"_links":{"self":[{"href":"http:\/\/10.11.101.25\/wordpress\/vivax\/wp-json\/wp\/v2\/posts\/1917"}],"collection":[{"href":"http:\/\/10.11.101.25\/wordpress\/vivax\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/10.11.101.25\/wordpress\/vivax\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/10.11.101.25\/wordpress\/vivax\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"http:\/\/10.11.101.25\/wordpress\/vivax\/wp-json\/wp\/v2\/comments?post=1917"}],"version-history":[{"count":28,"href":"http:\/\/10.11.101.25\/wordpress\/vivax\/wp-json\/wp\/v2\/posts\/1917\/revisions"}],"predecessor-version":[{"id":2276,"href":"http:\/\/10.11.101.25\/wordpress\/vivax\/wp-json\/wp\/v2\/posts\/1917\/revisions\/2276"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/10.11.101.25\/wordpress\/vivax\/wp-json\/wp\/v2\/media\/1919"}],"wp:attachment":[{"href":"http:\/\/10.11.101.25\/wordpress\/vivax\/wp-json\/wp\/v2\/media?parent=1917"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/10.11.101.25\/wordpress\/vivax\/wp-json\/wp\/v2\/categories?post=1917"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/10.11.101.25\/wordpress\/vivax\/wp-json\/wp\/v2\/tags?post=1917"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}