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Department of Tropical Hygiene, FTM
 
  Faculty Staff
 
 
Direk Limmathurotsakul  
Name: Direk Limmathurotsakul
Position: Associate Professor
Department: Tropical Hygiene
E-mail: direk.lim@mahidol.ac.th
   
 
Field of Expertise   |   Publications   |   Academic Qualification   |   Award
 
     
2014
   Limmathurotsakul D*, Wongsuvan G, Aanensen D, Ngamwilai S, Saiprom N, Rongkard P, Thaipadungpanit J, Kanoksil M, Chantratita N, Day NP, Peacock SJ. Melioidosis Caused by Burkholderia pseudomallei in Drinking Water, Thailand, 2012. Emerg Infect Dis 2014 Feb;20(2):265-8.  
       
    Myers ND*, Chantratita N, Berrington WR, Chierakul W, Limmathurotsakul D, Wuthiekanun V, Robertson JD, Liggitt HD, Peacock SJ, Skerrett SJ, West TE. The Role of NOD2 in Murine and Human Melioidosis. J Immunol 2014 Jan 1;192(1):300-7.  
       
2013
   Chantratita N, Tandhavanant S, Wongsuvan G, Wuthiekanun V, Teerawattanasook N, Day NP, Limmathurotsakul D, Peacock SJ.  Rapid detection of Burkholderia pseudomallei in blood cultures using a monoclonal antibody-based immunofluorescent assay. Am J Trop Med Hyg. 2013 Nov;89(5):971-2.  
       
    Cheng AC, Currie BJ, Dance DA, Funnell SG, Limmathurotsakul D, Simpson AJ, Peacock SJ. Clinical definitions of melioidosis. Am J Trop Med Hyg. 2013 Mar;88(3):411-3.  
       
    Chetchotisakd P, Chierakul W, Chaowagul W, Anunnatsiri S, Phimda K, Mootsikapun P, Chaisuksant S, Pilaikul J, Thinkhamrop B, Phiphitaporn S, Susaengrat W, Toondee C, Wongrattanacheewin S, Wuthiekanun V, Chantratita N, Thaipadungpanit J, Day NP, Limmathurotsakul D, Peacock SJ. Trimethoprim-sulfamethoxazole versus trimethoprim-sulfamethoxazole plus doxycycline as oral eradicative treatment for melioidosis (MERTH): a multicentre,double-blind, non-inferiority, randomised controlled trial. Lancet. 2013 Nov 22. pii: S0140-6736(13)61951-0.  
       
    Jarvis JN, Bicanic T, Loyse A, Namarika D, Jackson A, Nussbaum JC, Longley N, Muzoora C, Phulusa J, Taseera K, Kanyembe C, Wilson D, Hosseinipour MC, Brouwer AE, Limmathurotsakul D, White N, van der Horst C, Wood R, Meintjes G, Bradley J,  Jaffar S, Harrison T. Determinants of Mortality in a Combined Cohort of 501 Patients With HIV-Associated Cryptococcal Meningitis: Implications for Improving  Outcomes. Clin Infect Dis. 2013 Dec 26.  
       
    Kanoksil M, Jatapai A, Peacock SJ, Limmathurotsakul D. Correction: Epidemiology, Microbiology and Mortality Associated with Community-Acquired Bacteremia in Northeast Thailand: A Multicenter Surveillance Study. PLoS One. 2013 Oct 16;8(10).  
       
    Koh GC, Schreiber MF, Bautista R, Maude RR, Dunachie S, Limmathurotsakul D, Day NP, Dougan G, Peacock SJ. Host responses to melioidosis and tuberculosis are  both dominated by interferon-mediated signaling. PLoS One. 2013;8(1):e54961.  
       
    Kurt K, Rasigade JP, Laurent F, Goering RV, Žemličková H, Machova I, Struelens MJ, Zautner AE, Holtfreter S, Bröker B, Ritchie S, Reaksmey S, Limmathurotsakul D, Peacock SJ, Cuny C, Layer F, Witte W, Nübel U. Subpopulations of Staphylococcus aureus clonal complex 121 are associated with distinct clinical entities. PLoS One. 2013;8(3):e58155.  
       
    Lim C, Wannapinij P, White L, Day NP, Cooper BS, Peacock SJ, Limmathurotsakul  D. Using a web-based application to define the accuracy of diagnostic tests when  the gold standard is imperfect. PLoS One. 2013 Nov 12;8(11):e79489.  
       
    Limmathurotsakul D, Dance DA, Wuthiekanun V, Kaestli M, Mayo M, Warner J, Wagner DM, Tuanyok A, Wertheim H, Yoke Cheng T, Mukhopadhyay C, Puthucheary S, Day NP, Steinmetz I, Currie BJ, Peacock SJ. Systematic review and consensus guidelines for environmental sampling of Burkholderia pseudomallei. PLoS Negl Trop Dis. 2013;7(3):e2105.  
       
    Limmathurotsakul D, Kanoksil M, Wuthiekanun V, Kitphati R, deStavola B, Day NP, Peacock SJ. Activities of daily living associated with acquisition of melioidosis in northeast Thailand: a matched case-control study. PLoS Negl Trop Dis. 2013;7(2):e2072.  
       
    Luangasanatip N, Hongsuwan M, Lubell Y, Limmathurotsakul D, Teparrukkul P, Chaowarat S, Day NP, Graves N, Cooper BS. Long-term survival after intensive care unit discharge in Thailand: a retrospective study. Crit Care. 2013 Oct 3;17(5):R219.  
       
    Pan-ngum W, Blacksell SD, Lubell Y, Pukrittayakamee S, Bailey MS, de Silva HJ, Lalloo DG, Day NP, White LJ, Limmathurotsakul D. Estimating the true accuracy of diagnostic tests for dengue infection using bayesian latent class models. PLoS One. 2013;8(1):e50765.  
       
    Sonthayanon P, Chierakul W, Wuthiekanun V, Limmathurotsakul D, Amornchai P, Smythe LD, Day NP, Peacock SJ. Molecular confirmation of co-infection by pathogenic Leptospira spp. and Orientia tsutsugamushi in patients with acute febrile illness in Thailand. Am J Trop Med Hyg. 2013 Oct;89(4):797-9.  
       
    Stoesser N, Emary K, Soklin S, Peng An K, Sophal S, Chhomrath S, Day NP, Limmathurotsakul D, Nget P, Pangnarith Y, Sona S, Kumar V, Moore CE, Chanpheaktra N, Parry CM. The value of intermittent point-prevalence surveys of healthcare-associated infections for evaluating infection control interventions at Angkor Hospital for Children, Siem Reap, Cambodia. Trans R Soc Trop Med Hyg. 2013 Apr;107(4):248-53.  
       
    Suntornsut P, Kasemsupat K, Silairatana S, Wongsuvan G, Jutrakul Y, Wuthiekanun V, Day NP, Peacock SJ, Limmathurotsakul D.    Prevalence of melioidosis  in patients with suspected pulmonary tuberculosis and sputum smear negative for acid-fast bacilli in northeast Thailand.  Am J Trop Med Hyg. 2013 Nov;89(5):983-5.  
       
    Tandhavanant S, Wongsuvan G, Wuthiekanun V, Teerawattanasook N, Day NP, Limmathurotsakul D, Peacock SJ, Chantratita N. Monoclonal antibody-based immunofluorescence microscopy for the rapid identification of Burkholderia pseudomallei in clinical specimens. Am J Trop Med Hyg. 2013 Jul;89(1):165-8.  
       
    Thaipadungpanit J, Wuthiekanun V, Chantratita N, Yimsamran S, Amornchai P, Boonsilp S, Maneeboonyang W, Tharnpoophasiam P, Saiprom N, Mahakunkijcharoen Y, Day NP, Singhasivanon P, Peacock SJ, Limmathurotsakul D.  Leptospira species in floodwater during the 2011 floods in the Bangkok Metropolitan Region, Thailand. Am J Trop Med Hyg. 2013 Oct;89(4):794-6.  
       
    West TE, Chantratita N, Chierakul W, Limmathurotsakul D, Wuthiekanun V, Myers ND, Emond MJ, Wurfel MM, Hawn TR, Peacock SJ, Skerrett SJ. Impaired TLR5 functionality is associated with survival in melioidosis. J Immunol. 2013 Apr 1;190(7):3373-9.  
       
    Wuthiekanun V, Amornchai P, Paris DH, Langla S, Thaipadunpanit J, Chierakul W, Smythe LD, White NJ, Day NP, Limmathurotsakul D, Peacock SJ. Rapid isolation and susceptibility testing of Leptospira spp. using a new solid medium, LVW agar. Antimicrob Agents Chemother. 2013 Jan;57(1):297-302.  
       
2012
   Chantratita N*, Tandhavanant S, Wikraiphat C, Trunck LA, Rholl DA, Thanwisai A, Saiprom N, Limmathurotsakul D, Korbsrisate S, Day NPJ, Schweizer HP, Peacock SJ.   Proteomic analysis of colony morphology variants of Burkholderia pseudomallei defines a role for the arginine deiminase system in bacterial survival. J Proteomics 2012 Jan;75(3):1031-42.  
       
    Desakorn V*, Wuthiekanun V, Thanachartwet V, Sahassananda D, Chierakul W, Apiwattanaporn A, Day NP, Limmathurotsakul D, Peacock SJ.   Accuracy of a Commercial IgM ELISA for the Diagnosis of Human Leptospirosis in Thailand. Am J Trop Med Hyg 2012 Mar;86(3):524-7.  
       
    Limmathurotsakul D *, Thammasart S, Warrasuth N, Thapanagulsak P, Jatapai A, Pengreungrojanachai V, Anun S, Joraka W, Thongkamkoon P, Saiyen P, Wongratanacheewin S, Day NPJ, Peacock SJ. Melioidosis in animals, Thailand, 2006-2010. Emerg Infect Dis 2012 Feb;18(2):325-7.  
       
    Limmathurotsakul D*, Turner EL, Wuthiekanun V, Thaipadungpanit J, Suputtamongkol Y, Chierakul W, Smythe LD, Day NPJ, Cooper B, Peacock SJ. Fool's gold: Why imperfect reference tests are undermining the evaluation of novel diagnostics: A reevaluation of 5 diagnostic tests for leptospirosis. Clin Infect Dis 2012 Aug;55(3):322-31.  
       
    Limmathurotsakul D*, Wuthiekanun V, Amornchai P, Wongsuwan G, Day NPJ, Peacock SJ. Effectiveness of a simplified method for isolation of Burkholderia pseudomallei from soil. Appl Environ Microb 2012 Feb;78(3):876-7.  
       
    Mahavanakul W, Nickerson EK, Srisomang P, Teparrukkul P, Lorvinitnun P, Wongyingsinn M, Chierakul W, Hongsuwan M, West TE, Day NP, Limmathurotsakul D, Peacock SJ. Feasibility of Modified Surviving Sepsis Campaign Guidelines in a Resource-Restricted Setting Based on a Cohort Study of Severe S. Aureus Sepsis. PLoS One 2012 Feb;7(2):e29858.  
       
    Maude RR*, Vatcharapreechasakul T, Ariyaprasert P, Maude RJ, Hongsuwan M, Yuentrakul P, Limmathurotsakul D, Koh GCKW, Chaowagul W, Day NPJ, Peacock SJ. Prospective observational study of the frequency and features of intra-abdominal abscesses in patients with melioidosis in northeast Thailand. Trans Roy Soc Trop Med Hyg 2012 Oct;106(10):629-31.  
       
    Peacock SJ, Limmathurotsakul D*, Lubell Y, Koh GCKW, White LJ, Day NPJ, Titball RW. Melioidosis vaccines: A systematic review and appraisal of the potential to exploit biodefense vaccines for public health purposes. PLoS Negl Trop Dis 2012 Jan;6(1):e1488.  
       
    Price EP, Dale JL, Cook JM, Sarovich DS, Seymour ML, Ginther JL, Kaufman EL, Beckstrom-Sternberg SM, Mayo M, Kaestli M, Glass MB, Gee JE, Wuthiekanun V, Warner JM, Baker A, Foster JT, Tan P, Tuanyok A, Limmathurotsakul D, Peacock SJ, Currie BJ, Wagner DM, Keim P, Pearson T. Development and validation of burkholderia pseudomallei-specific real-time pcr assays for clinical, environmental or forensic detection applications. PLoS One 2012 May;7(5):e37723.  
       
    Stoesser N, Pocock J, Moore CE, Soeng S, Chhat HP, Sar P, Limmathurotsakul D, Day N, Thy V, Sar V, Parry CM. Pediatric suppurative parotitis in cambodia between 2007 and 2011. Pediatr Infect Dis J 2012 Aug;31(8):865-8.  
       
    Velapatiño B, Limmathurotsakul D, Peacock SJ, Speert DP. Identification of differentially expressed proteins from Burkholderia pseudomallei isolated during primary and relapsing melioidosis. Microbes Infect 2012 Apr;14(4):335-40.  
       
    West TE, Chierakul W, Chantratita N, Limmathurotsakul D, Wuthiekanun V, Emond MJ, Hawn TR, Peacock SJ, Skerrett SJ. Toll-like receptor 4 region genetic variants are associated with susceptibility to melioidosis. Genes Immun 2012 Jan;13(1):38-46.  
       
2011
   Limmathurotsakul D, Chantratita N, Teerawattanasook N, Piriyagitpaiboon K, Thanwisai A, Wuthiekanun V, Day NP, Cooper B, Peacock SJ (2011) Enzyme-linked immunosorbent assay for the diagnosis of melioidosis: better than we thought. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 52: 1024-1028.  
       
    Limmathurotsakul D, Peacock SJ (2011) Melioidosis: a clinical overview. British medical bulletin 99: 125-139.  
       
    Limmathurotsakul D, Wuthiekanun V, Wongsuvan G, Pangmee S, Amornchai P, Teparrakkul P, Teerawattanasook N, Day NP, Peacock SJ (2011) Repeat blood culture positive for B. pseudomallei indicates an increased risk of death from melioidosis. The American journal of tropical medicine and hygiene 84: 858-861.  
       
    Limmathurotsakul D, Cooper B, Peacock SJ, De Stavola B (2011) Long-term outcome of Q fever endocarditis. The Lancet infectious diseases 11: 81; author reply 82.  
       
2010
   Chantratita N, Rholl DA, Sim B, Wuthiekanun V, Limmathurotsakul D, Amornchai P, Thanwisai A, Chua HH, Ooi WF, Holden MTG, Day NP, Tan P, Schweizer HP, Peacock SJ*. Antimicrobial resistance to ceftazidime involving loss of penicillin-binding protein 3 in Burkholderia pseudomallei.   Proc Natl Acad Sci U S A 2011 Oct;108(41):17165-70.  
       
    Koh G, Maude RR, Schreiber MF, Limmathurotsakul D, Wiersinga WJ, Wuthiekanun V, Lee SJ, Mahavanakul W, Chaowagul W, Chierakul W, White NJ, van der Poll T, Day NPJ, Dougan G, Peacock SJ. Glyburide Is Anti-inflammatory and Associated with Reduced Mortality in Melioidosis. Clin Inf Dis 2011 Mar;52(6):717-25.  
       
    Limmathurotsakul D*, Chantratita N, Teerawattanasook N, Piriyagitpaiboon K, Thanwisai A, Wuthiekanun V, Day NPJ, Cooper B, Peacock SJ. Enzyme-linked immunosorbent assay for the diagnosis of melioidosis: Better than we thought. Clin Inf Dis 2011 Apr;52(8):1024-8.  
       
    Limmathurotsakul D*, Cooper B, Peacock SJ, De Stavola B. Long-term outcome of Q fever endocarditis. Lancet Infect Dis 2011 Feb;11(2):81.  
       
    Limmathurotsakul D, Peacock SJ. Melioidosis: a clinical overview. Br Med Bull 2011 Sep;99(1):125-39.  
       
    Limmathurotsakul D, Wuthiekanun V, Wongsuvan G, Pangmee S, Amornchai P, Teparrakkul P, Teerawattanasook N, Day NPJ, Peacock SJ. Short report: Repeat blood culture positive for B. pseudomallei indicates an increased risk of death from melioidosis. Am J Trop Med Hyg 2011 Jun;84(6):858-61.  
       
    Sonthayanon P*, Chierakul W, Wuthiekanun V, Thaipadungpanit J, Kalambaheti T, Boonsilp S, Amornchai P, Smythe LD, Limmathurotsakul D, Day NP, Peacock SJ. Accuracy of Loop-Mediated Isothermal Amplification for Diagnosis of Human Leptospirosis in Thailand. Am J Trop Med Hyg 2011 Apr;84(4):614-20.  
       
    Suwannasaen D, Mahawantung J, Chaowagul W, Limmathurotsakul D, Felgner PL, Davies H, Bancroft GJ, Titball RW, Lertmemongkolchai G. Human Immune Responses to Burkholderia pseudomallei Characterized by Protein Microarray Analysis. J Infect Dis 2011;203(7):1002-11.  
       
    Thaipadunpanit J*, Chierakul W, Wuthiekanun V, Limmathurotsakul D, Amornchai P, Boonslip S, Smythe LD, Limpaiboon R, Hoffmaster AR, Day NPJ, Peacock SJ. Diagnostic accuracy of real-time PCR assays targeting 16S rRNA and lipl32 genes for human leptospirosis in Thailand: A case-control study. PLoS ONE 2011 Jan;6(1):e16236.  
       
    Trung TT, Hetzer A, Gohler A, Topfstedt E, Wuthiekanun V, Limmathurotsakul D, Peacock SJ, Steinmetz I. Highly Sensitive Direct Detection and Quantification of Burkholderia pseudomallei Bacteria in Environmental Soil Samples by Using Real-Time PCR. Appl Environ Microbiol 2011 Sep;77(18):6486-94.  
       
    Trung TT, Hetzer A, Topfstedt E, Gohler A, Limmathurotsakul D, Wuthiekanun V, Peacock SJ, Steinmetz I. Improved culture-based detection and quantification of Burkholderia pseudomallei from soil. Trans R Soc Trop Med Hyg 2011 Jun;105(6):346-51.  
       
    Wuthiekanun V, Amornchai P, Saiprom N, Chantratita N, Chierakul W, Koh G, Chaowagul W, Day NPJ, Limmathurotsakul D*, Peacock SJ.  Survey of Antimicrobial Resistance in Clinical Burkholderia pseudomallei Isolates over Two Decades in Northeast Thailand. Antimicrob Agents Chemother 2011 Nov;55(11):5388-91.  
 
Last updated: June 10, 2019
  
 
 
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