Malaria transmission; MVRU research on transmission of malaria is aimed to improve our understanding of how mobile human, populations, parasite drug resistance, and mosquito biology contribute to continuous malaria transmission at international borders so that innovative control strategies can be developed to support regional malaria elimination
Past Project
Characterization of Plasmodium vivax gametocyte and its association with mosquito infectivity
Topic of research
International Laboratory Installation and Collaborative Research on Neglected Tropical and Vector-borne Diseases.
Outcome
Characterization of gametocyte development will lead to the discovery of the gametocyte markers which relate to the transmission of the parasite to mosquito. These markers can be used to determine the level of contribution to transmission of reservoir populations as well as to support the development of transmission blocking vaccines/drugs.
Key Information
Key MVRU Researchers:
Project Status:
Past
Funded by:
- National institute of Allergy and infectious diseases
- Korean national institute of health
In collaboration with:
- Liwang Cui, Professor, University of South Florida
- Takafumi Tsuboi, Professor, Proteo-Science Center, Ehime University
- Tomoko Ishino, Associate Professor, Proteo-Science Center, Ehime University
- Motomi Torii, Professor, Proteo-Science Center, Ehime University
- Eizo Takashima , Associate Professor, Proteo-Science Center, Ehime University
On-going Project
Development of Plasmodium vivax gametocyte and its association with mosquito infectivity
Topic of research
Support deep knowledge base research. Also promote and support new researchers to continue research and stepping into higher-level research work.
Outcome
The information on P. vivax gametocyte development will give a better understanding of gametocyte biology and their infectiveness to the mosquito, allowing future identification of novel candidates for transmission blocking vaccines/drugs.
On-going Project
Transcriptomes and Proteomes of Plasmodium vivax
Topic of research
Exploratory/Developmental research
Outcome
This study depict a comprehensive view of gene expression of P. vivax blood stage. Such information will help unravel the mechanism of sexual development which may lead to the discovery of new antimalarial drugs and transmission-blocking vaccine targets. This information will definitely fuel malaria elimination.
Key Information
Key MVRU Researchers:
Project Status:
On-going
Funded by:
- National institute of Allergy and infectious diseases
In collaboration with:
- Liwang Cui, Professor, University of South Florida