Our laboratory is interested in mechanisms of neuronal degeneration during aging, particularly in Alzheimer’s disease (AD). The brain loses neurons and connections between cells due to aging, injury, or disease. When these losses reach above a certain threshold and the neuronal regeneration is minimal in the adult brain, people develop clinical symptoms. So far, no effective therapeutic strategies for AD have been successfully developed despite its increasing rate in elderly. The major challenge of AD therapy is a lack of profound understanding of key mechanisms that underlie pathogenesis. Thus, we focus on identifying how cell biological processes are disrupted in AD using the cultured neurons and the rat model. In particular, we examine mechanisms involving the early onset of the disease that is associated with an imbalance of the cellular redox system. Moreover, owing to a variety of plants and organisms in Thailand, our research interests extend to a phenotype-based screening for botanical compounds that are potential for AD prevention and therapy. We use a wide range of approaches, including biochemistry, molecular and cellular biology, pharmacology, immunohistochemistry, confocal and electron microscopy, cell culture, and animal modeling.