Malaria Genomics and Transcriptomics
Drug and Vaccine development; MVRU and its partners have been a pioneer in discovering and testing new vaccines candidates for malaria transmission (TBVs), erythrocyte invasion, sporozoite invasion as well as testing new anti-malarial compounds against hypnozoites.
On-going Project
Plasmodium vivax Volunteer Infection Studies in Thailand
Topic of research
Plasmodium vivax Volunteer Infection Studies in Thailand
Outcome
The vast majority of malaria vaccinology has focussed on P. falciparum and animal models. These animal models have provided fundamental insights into malaria immunity and allowed down-selection of vaccine candidates but none reproduce the human condition in endemic areas. Vaccine development in P. vivax has been relatively neglected. Vivax CHMI model in Southeast Asia, the heartland of vivax malaria, will advance vivax vaccine development to 2 major roles
- testing candidate vaccines to accelerate licensure among the current generation of vaccines.
- identifying immunological correlates of protection to guide development of the next generation of vaccines.
Key Information
Project Status:
On-going
Funded by:
- Welcome Trust
Past Project
The development of Invasion inhibition assay for vaccine screening of Plasmodium vivax
Topic of research
Basic research related to Tropical diseases.
Outcome
Established high throughput invasion assay for in vitro vaccine screening of Plasmodium vivax. The optimized invasion assay will increase accuracy, productivity, and throughput of the assay which will fasten the antimalarial drugs/vaccines discovery.
Publications:
Key Information
Key MVRU Researchers:
Project Status:
Past
Funded by:
- Bill & Melinda Gates Foundation
- Mahidol university
- Korean national institute of health
On-going Project
Elucidating the Mechanism of Reticulocyte-Specific Invasion by Plasmodium vivax
Topic of research
Better understanding of P. vivax biology
Outcome
This project aims to provide a better understanding of the molecular process underlying how P. vivax senses and selects young erythrocyte to invade.
Key Information
Key MVRU Researchers:
Project Status:
On-going
Funded by:
- Welcome Trust